5d8e

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==crystal structure of SSB from homo sapiens==
==crystal structure of SSB from homo sapiens==
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<StructureSection load='5d8e' size='340' side='right' caption='[[5d8e]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='5d8e' size='340' side='right'caption='[[5d8e]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5d8e]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8E OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D8E FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5d8e]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D8E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D8E FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5d8f|5d8f]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8e OCA], [http://pdbe.org/5d8e PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d8e RCSB], [http://www.ebi.ac.uk/pdbsum/5d8e PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8e ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d8e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d8e OCA], [https://pdbe.org/5d8e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d8e RCSB], [https://www.ebi.ac.uk/pdbsum/5d8e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d8e ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN]] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
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[https://www.uniprot.org/uniprot/SOSB1_HUMAN SOSB1_HUMAN] Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.<ref>PMID:18449195</ref> <ref>PMID:19605351</ref> <ref>PMID:19683501</ref>
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==See Also==
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*[[Single-stranded DNA-binding protein 3D structures|Single-stranded DNA-binding protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Dong, Y H]]
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[[Category: Homo sapiens]]
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[[Category: Gao, Z Q]]
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[[Category: Large Structures]]
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[[Category: Li, Y H]]
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[[Category: Dong YH]]
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[[Category: Dna binding protein]]
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[[Category: Gao ZQ]]
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[[Category: Single-strand dna binding]]
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[[Category: Li YH]]

Current revision

crystal structure of SSB from homo sapiens

PDB ID 5d8e

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