5i5n

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==Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Acidic pH.==
==Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Acidic pH.==
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<StructureSection load='5i5n' size='340' side='right' caption='[[5i5n]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
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<StructureSection load='5i5n' size='340' side='right'caption='[[5i5n]], [[Resolution|resolution]] 1.42&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i5n]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I5N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i5n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thogoto_thogotovirus Thogoto thogotovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I5N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I5N FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i5o|5i5o]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.418&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5n OCA], [http://pdbe.org/5i5n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i5n RCSB], [http://www.ebi.ac.uk/pdbsum/5i5n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i5n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i5n OCA], [https://pdbe.org/5i5n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i5n RCSB], [https://www.ebi.ac.uk/pdbsum/5i5n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i5n ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/ML_THOGV ML_THOGV] Blocks host IRF3 and IRF7, thereby inhibiting IFN-beta expression and activation of host antiviral state.<ref>PMID:15582653</ref> <ref>PMID:18768974</ref> <ref>PMID:19812269</ref>
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The matrix proteins of orthomyxoviruses, including influenza virus, infectious salmon anemia virus and Thogoto virus, play crucial roles in essential processes of the viral life cycle. However, the mechanisms of the matrix proteins involved in these processes are not fully understood. Currently, only the structure and function of the matrix protein from influenza virus have been studied. Here, we present the crystal structures of the N-terminal domain of matrix protein from Thogoto virus at pH 7.0 and 4.5. By analyzing the structures, we identified the conformational changes of monomers and dimers in different pH conditions, mainly caused by two flexible loops, L3 and L5. We suggest these structural deviations would reflect the basis of viral capsid assembly or disassembly.
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Conformational changes of matrix protein from Thogoto virus at different pH implicate the mechanism of viral assembly and uncoating.,Yang M, Feng F, Liu Y, Wang H, Yang Z, Hou W, Liang H J Gen Virol. 2016 Jul 13. doi: 10.1099/jgv.0.000551. PMID:27411929<ref>PMID:27411929</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5i5n" style="background-color:#fffaf0;"></div>
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== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Liang, H]]
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[[Category: Large Structures]]
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[[Category: Liu, Y]]
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[[Category: Thogoto thogotovirus]]
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[[Category: Yang, M]]
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[[Category: Liang H]]
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[[Category: Viral protein]]
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[[Category: Liu Y]]
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[[Category: Yang M]]

Current revision

Crystal Structure of N-terminal Domain of Matrix Protein of Thogoto Virus at Acidic pH.

PDB ID 5i5n

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