5a5i
From Proteopedia
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==Cytochrome 2C9 P450 inhibitor complex== | ==Cytochrome 2C9 P450 inhibitor complex== | ||
| - | <StructureSection load='5a5i' size='340' side='right' caption='[[5a5i]], [[Resolution|resolution]] 2.00Å' scene=''> | + | <StructureSection load='5a5i' size='340' side='right'caption='[[5a5i]], [[Resolution|resolution]] 2.00Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5a5i]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5I OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5a5i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A5I FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=XI1:N-[4-(3-CHLORANYL-4-CYANO-PHENOXY)CYCLOHEXYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>XI1</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=XI1:N-[4-(3-CHLORANYL-4-CYANO-PHENOXY)CYCLOHEXYL]-1,1,1-TRIS(FLUORANYL)METHANESULFONAMIDE'>XI1</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a5i OCA], [https://pdbe.org/5a5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a5i RCSB], [https://www.ebi.ac.uk/pdbsum/5a5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a5i ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CP2C9_HUMAN CP2C9_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan. |
| + | |||
| + | ==See Also== | ||
| + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Phillips | + | [[Category: Large Structures]] |
| - | [[Category: Skerratt | + | [[Category: Phillips C]] |
| - | [[Category: | + | [[Category: Skerratt SE]] |
| + | [[Category: De Groot MJ]] | ||
Current revision
Cytochrome 2C9 P450 inhibitor complex
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