1op1

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[[Image:1op1.gif|left|200px]]
 
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{{Structure
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==Solution NMR structure of domain 1 of receptor associated protein==
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|PDB= 1op1 |SIZE=350|CAPTION= <scene name='initialview01'>1op1</scene>
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<StructureSection load='1op1' size='340' side='right'caption='[[1op1]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1op1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OP1 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= LRPAP1 OR A2MRAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1op1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1op1 OCA], [https://pdbe.org/1op1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1op1 RCSB], [https://www.ebi.ac.uk/pdbsum/1op1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1op1 ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Disease ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1op1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1op1 OCA], [http://www.ebi.ac.uk/pdbsum/1op1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1op1 RCSB]</span>
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[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN] Note=In complex with the alpha-2-MR or gp330, it may have some role in the pathogenesis of membrane glomerular nephritis.
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}}
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== Function ==
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[https://www.uniprot.org/uniprot/AMRP_HUMAN AMRP_HUMAN] Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
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'''Solution NMR structure of domain 1 of receptor associated protein'''
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==Overview==
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<jmolCheckbox>
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The 39 kDa receptor associated protein (RAP) is a modular protein consisting of multiple domains. There has been no x-ray crystal structure of RAP available and the full-length protein does not behave well in a NMR tube. To elucidate the 3D structure of the RAP, we undertook structure determination of individual domains of the RAP. As the first step, here we report the nearly complete assignments of the (1)H, (13)C and (15)N chemical shift signals of domain 1 of the RAP.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/op/1op1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1OP1 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OP1 OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1op1 ConSurf].
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==Reference==
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<div style="clear:both"></div>
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1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein., Wu Y, Migliorini M, Yu P, Strickland DK, Wang YX, J Biomol NMR. 2003 Jun;26(2):187-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12766414 12766414]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Migliorini, M.]]
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[[Category: Migliorini M]]
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[[Category: Strickland, D K.]]
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[[Category: Strickland DK]]
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[[Category: Wang, Y-X.]]
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[[Category: Wang Y-X]]
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[[Category: Wu, Y.]]
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[[Category: Wu Y]]
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[[Category: Yu, P.]]
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[[Category: Yu P]]
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[[Category: helical bundle]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:48:18 2008''
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Current revision

Solution NMR structure of domain 1 of receptor associated protein

PDB ID 1op1

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