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5kn5

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==TGFalpha/Epiregulin complex with neutralizing antibody LY3016859==
==TGFalpha/Epiregulin complex with neutralizing antibody LY3016859==
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<StructureSection load='5kn5' size='340' side='right' caption='[[5kn5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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<StructureSection load='5kn5' size='340' side='right'caption='[[5kn5]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kn5]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KN5 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KN5 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kn5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KN5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KN5 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kn5 OCA], [http://pdbe.org/5kn5 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kn5 RCSB], [http://www.ebi.ac.uk/pdbsum/5kn5 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kn5 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kn5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kn5 OCA], [https://pdbe.org/5kn5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kn5 RCSB], [https://www.ebi.ac.uk/pdbsum/5kn5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kn5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN]] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
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[https://www.uniprot.org/uniprot/TGFA_HUMAN TGFA_HUMAN] TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5kn5" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5kn5" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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*[[3D structures of human antibody|3D structures of human antibody]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atwell, S]]
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[[Category: Homo sapiens]]
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[[Category: Boyles, J S]]
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[[Category: Large Structures]]
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[[Category: Clawson, D K]]
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[[Category: Atwell S]]
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[[Category: Druzina, Z]]
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[[Category: Boyles JS]]
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[[Category: Josef, G H]]
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[[Category: Clawson DK]]
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[[Category: Weichert, K]]
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[[Category: Druzina Z]]
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[[Category: Witcher, D R]]
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[[Category: Josef GH]]
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[[Category: Immune system]]
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[[Category: Weichert K]]
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[[Category: Tgfalpha epiregulin antibody fab]]
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[[Category: Witcher DR]]

Current revision

TGFalpha/Epiregulin complex with neutralizing antibody LY3016859

PDB ID 5kn5

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