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5l3j

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==ESCHERICHIA COLI DNA GYRASE B IN COMPLEX WITH BENZOTHIAZOLE-BASED INHIBITOR==
==ESCHERICHIA COLI DNA GYRASE B IN COMPLEX WITH BENZOTHIAZOLE-BASED INHIBITOR==
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<StructureSection load='5l3j' size='340' side='right' caption='[[5l3j]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
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<StructureSection load='5l3j' size='340' side='right'caption='[[5l3j]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l3j]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L3J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L3J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l3j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L3J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L3J FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6G9:2-[[2-[[4,5-BIS(BROMANYL)-1~{H}-PYRROL-2-YL]CARBONYLAMINO]-1,3-BENZOTHIAZOL-6-YL]AMINO]-2-OXIDANYLIDENE-ETHANOIC+ACID'>6G9</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_topoisomerase_(ATP-hydrolyzing) DNA topoisomerase (ATP-hydrolyzing)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.99.1.3 5.99.1.3] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6G9:2-[[2-[[4,5-BIS(BROMANYL)-1~{H}-PYRROL-2-YL]CARBONYLAMINO]-1,3-BENZOTHIAZOL-6-YL]AMINO]-2-OXIDANYLIDENE-ETHANOIC+ACID'>6G9</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l3j OCA], [http://pdbe.org/5l3j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l3j RCSB], [http://www.ebi.ac.uk/pdbsum/5l3j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l3j ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l3j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l3j OCA], [https://pdbe.org/5l3j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l3j RCSB], [https://www.ebi.ac.uk/pdbsum/5l3j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l3j ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref>
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[https://www.uniprot.org/uniprot/GYRB_ECOLI GYRB_ECOLI] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.<ref>PMID:12051843</ref> <ref>PMID:18642932</ref> <ref>PMID:20675723</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5l3j" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5l3j" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Barancokova, M]]
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[[Category: Escherichia coli]]
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[[Category: Gjorgjieva, M]]
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[[Category: Large Structures]]
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[[Category: Ilas, J]]
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[[Category: Barancokova M]]
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[[Category: Katsamakas, S]]
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[[Category: Gjorgjieva M]]
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[[Category: Kikelj, D]]
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[[Category: Ilas J]]
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[[Category: Masic, L Peterlin]]
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[[Category: Katsamakas S]]
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[[Category: Montalvao, S]]
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[[Category: Kikelj D]]
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[[Category: Tammella, P]]
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[[Category: Montalvao S]]
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[[Category: Tomasic, T]]
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[[Category: Peterlin Masic L]]
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[[Category: Complex]]
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[[Category: Tammella P]]
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[[Category: Gyrase b]]
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[[Category: Tomasic T]]
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[[Category: Gyrb]]
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[[Category: Inhibitor]]
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[[Category: Isomerase]]
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[[Category: Proteros biostructure]]
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[[Category: Proteros biostructures gmbh]]
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Current revision

ESCHERICHIA COLI DNA GYRASE B IN COMPLEX WITH BENZOTHIAZOLE-BASED INHIBITOR

PDB ID 5l3j

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