5kuh

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==GluK2EM with LY466195==
==GluK2EM with LY466195==
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<StructureSection load='5kuh' size='340' side='right' caption='[[5kuh]], [[Resolution|resolution]] 11.60&Aring;' scene=''>
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<SX load='5kuh' size='340' side='right' viewer='molstar' caption='[[5kuh]], [[Resolution|resolution]] 11.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kuh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KUH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kuh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KUH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KUH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=LY5:(3S,4AR,6S,8AR)-6-{[(2S)-2-CARBOXY-4,4-DIFLUOROPYRROLIDIN-1-YL]METHYL}DECAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>LY5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 11.6&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5kuf|5kuf]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LY5:(3S,4AR,6S,8AR)-6-{[(2S)-2-CARBOXY-4,4-DIFLUOROPYRROLIDIN-1-YL]METHYL}DECAHYDROISOQUINOLINE-3-CARBOXYLIC+ACID'>LY5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuh OCA], [http://pdbe.org/5kuh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kuh RCSB], [http://www.ebi.ac.uk/pdbsum/5kuh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kuh OCA], [https://pdbe.org/5kuh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kuh RCSB], [https://www.ebi.ac.uk/pdbsum/5kuh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kuh ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT]] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
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[https://www.uniprot.org/uniprot/GRIK2_RAT GRIK2_RAT] Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2 (By similarity).<ref>PMID:17486098</ref> <ref>PMID:17115050</ref>
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==See Also==
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*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Chittori, S]]
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[[Category: Large Structures]]
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[[Category: Han, T H]]
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[[Category: Rattus norvegicus]]
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[[Category: Mayer, M L]]
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[[Category: Chittori S]]
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[[Category: Merk, A]]
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[[Category: Han TH]]
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[[Category: Meyerson, J R]]
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[[Category: Mayer ML]]
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[[Category: Rao, P]]
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[[Category: Merk A]]
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[[Category: Serpe, M]]
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[[Category: Meyerson JR]]
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[[Category: Subramaniam, S]]
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[[Category: Rao P]]
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[[Category: Gluk2em with ly466195]]
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[[Category: Serpe M]]
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[[Category: Signaling protein]]
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[[Category: Subramaniam S]]

Current revision

GluK2EM with LY466195

5kuh, resolution 11.60Å

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