5i0h

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==Crystal structure of myosin X motor domain in pre-powerstroke state==
==Crystal structure of myosin X motor domain in pre-powerstroke state==
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<StructureSection load='5i0h' size='340' side='right' caption='[[5i0h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='5i0h' size='340' side='right'caption='[[5i0h]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5i0h]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0H OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I0H FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5i0h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I0H FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hmo|5hmo]], [[5hmp|5hmp]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0h OCA], [http://pdbe.org/5i0h PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i0h RCSB], [http://www.ebi.ac.uk/pdbsum/5i0h PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0h ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i0h OCA], [https://pdbe.org/5i0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i0h RCSB], [https://www.ebi.ac.uk/pdbsum/5i0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i0h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN]] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref>
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[https://www.uniprot.org/uniprot/MYO10_HUMAN MYO10_HUMAN] Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate or integrins, and mediates cargo transport along actin filaments. Regulates cell shape, cell spreading and cell adhesion. Stimulates the formation and elongation of filopodia. May play a role in neurite outgrowth and axon guidance. Plays a role in formation of the podosome belt in osteoclasts (By similarity).<ref>PMID:16894163</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5i0h" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5i0h" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Myosin 3D Structures|Myosin 3D Structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Blanc, F]]
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[[Category: Homo sapiens]]
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[[Category: Houdusse, A]]
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[[Category: Large Structures]]
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[[Category: Isabet, T]]
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[[Category: Blanc F]]
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[[Category: Sweeney, H L]]
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[[Category: Houdusse A]]
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[[Category: Molecular motor]]
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[[Category: Isabet T]]
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[[Category: Motility]]
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[[Category: Sweeney HL]]
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[[Category: Motor domain]]
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[[Category: Motor protein]]
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[[Category: Myosin]]
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[[Category: Pre-powerstroke state]]
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Current revision

Crystal structure of myosin X motor domain in pre-powerstroke state

PDB ID 5i0h

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