5gvu

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m (Protected "5gvu" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5gvu is ON HOLD
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==crystal structure of BVDV NS3 helicase domain==
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<StructureSection load='5gvu' size='340' side='right'caption='[[5gvu]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5gvu]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bovine_viral_diarrhea_virus_1 Bovine viral diarrhea virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GVU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GVU FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gvu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gvu OCA], [https://pdbe.org/5gvu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gvu RCSB], [https://www.ebi.ac.uk/pdbsum/5gvu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gvu ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/POLG_BVDVN POLG_BVDVN] Initial binding to target cell probably involves interaction of E(rns) with glycosaminoglycans. E1 and/or E2 are responsible of cell attachment with CD46 and subsequent fusion after internalization of the virion by endocytosis (Probable).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> P7 forms a leader sequence to properly orient NS2 in the membrane (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> Uncleaved NS2-3 is required for production of infectious virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS2 protease seems to play a vital role in viral RNA replication control and in the pathogenicity of the virus.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> NS4A is a cofactor for the NS3 protease activity (By similarity).<ref>PMID:14963137</ref> <ref>PMID:16051874</ref> RNA-directed RNA polymerase NS5 replicates the viral (+) and (-) genome.<ref>PMID:14963137</ref> <ref>PMID:16051874</ref>
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Authors:
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==See Also==
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*[[Helicase 3D structures|Helicase 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bovine viral diarrhea virus 1]]
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[[Category: Large Structures]]
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[[Category: Li S]]
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[[Category: Mao X]]

Current revision

crystal structure of BVDV NS3 helicase domain

PDB ID 5gvu

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OCA

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