5hsi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of tyrosine decarboxylase at 1.73 Angstroms resolution== | |
| - | + | <StructureSection load='5hsi' size='340' side='right'caption='[[5hsi]], [[Resolution|resolution]] 1.73Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5hsi]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Levilactobacillus_brevis Levilactobacillus brevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HSI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.732Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | [[Category: Ni | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hsi OCA], [https://pdbe.org/5hsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hsi RCSB], [https://www.ebi.ac.uk/pdbsum/5hsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hsi ProSAT]</span></td></tr> |
| - | [[Category: Zhang | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TYRDC_LEVBR TYRDC_LEVBR] Catalyzes the decarboxylation of L-tyrosine to produce tyramine (PubMed:24211777, PubMed:27292129). Cannot use other aromatic L-amino acids as substrates like L-phenylalanine, L-tryptophan and L-glutamate (PubMed:24211777).<ref>PMID:24211777</ref> <ref>PMID:27292129</ref> Is also able to decarboxylate the Parkinson's disease medication levodopa (L-dopa) to dopamine in vitro.<ref>PMID:24211777</ref> <ref>PMID:27292129</ref> |
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Levilactobacillus brevis]] | ||
| + | [[Category: Ni Y]] | ||
| + | [[Category: Zhang K]] | ||
| + | [[Category: Zhou J]] | ||
| + | [[Category: Zhu H]] | ||
Current revision
Crystal structure of tyrosine decarboxylase at 1.73 Angstroms resolution
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