5t4u

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'''Unreleased structure'''
 
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The entry 5t4u is ON HOLD until Paper Publication
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==Crystal structure of the bromodomain of human BRPF1 in complex with a quinolinone ligand==
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<StructureSection load='5t4u' size='340' side='right'caption='[[5t4u]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5t4u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T4U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=12Q:1-METHYLQUINOLIN-2(1H)-ONE'>12Q</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t4u OCA], [https://pdbe.org/5t4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t4u RCSB], [https://www.ebi.ac.uk/pdbsum/5t4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t4u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BRPF1_HUMAN BRPF1_HUMAN] Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. Positively regulates the transcription of RUNX1 and RUNX2.<ref>PMID:16387653</ref> <ref>PMID:18794358</ref>
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Authors: Tallant, C., Igoe, N., Bayle, E.D., Nunez-Alonso, G., Newman, J.A., Mathea, S., Savitsky, P., Fedorov, O., Brennan, P.E., Muller, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Fish, P., Knapp, S., Structural Genomics Consortium (SGC)
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==See Also==
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*[[Peregrin|Peregrin]]
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Description: Crystal structure of the bromodomain of human BRPF1 in complex with a quinolinone ligand
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Bayle, E.D]]
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__TOC__
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[[Category: Fish, P]]
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</StructureSection>
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[[Category: Igoe, N]]
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[[Category: Homo sapiens]]
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[[Category: Nunez-Alonso, G]]
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[[Category: Large Structures]]
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[[Category: Fedorov, O]]
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[[Category: Arrowsmith CH]]
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[[Category: Muller, S]]
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[[Category: Bayle ED]]
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[[Category: Knapp, S]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Brennan PE]]
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[[Category: Mathea, S]]
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[[Category: Edwards AM]]
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[[Category: Arrowsmith, C.H]]
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[[Category: Fedorov O]]
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[[Category: Von Delft, F]]
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[[Category: Fish P]]
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[[Category: Edwards, A.M]]
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[[Category: Igoe N]]
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[[Category: Brennan, P.E]]
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[[Category: Knapp S]]
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[[Category: Newman, J.A]]
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[[Category: Mathea S]]
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[[Category: Structural Genomics Consortium (Sgc)]]
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[[Category: Muller S]]
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[[Category: Tallant, C]]
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[[Category: Newman JA]]
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[[Category: Savitsky, P]]
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[[Category: Nunez-Alonso G]]
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[[Category: Savitsky P]]
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[[Category: Tallant C]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of the bromodomain of human BRPF1 in complex with a quinolinone ligand

PDB ID 5t4u

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OCA

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