5hlj

<StructureSection load='5hlj' size='340' side='right' caption='[[5hlj]], [[Resolution|resolution]] 2.41&Aring;' scene=''>

<table><tr><td colspan='2'>[[5hlj]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HLJ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HLJ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hlj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hlj OCA], [http://pdbe.org/5hlj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hlj RCSB], [http://www.ebi.ac.uk/pdbsum/5hlj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hlj ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

White spot syndrome virus (WSSV) is one of the major and most serious pathogen in the shrimp industry. As one of the most abundant envelope protein, VP24 acts as a core protein interacting with other structure proteins and plays an important role in virus assembly and infection. Here, we have presented the crystal structure of VP24 from WSSV. In the structure, VP24 consists of a nine-stranded beta-barrel fold with mostly antiparallel beta-strands, and the loops extending out the beta-barrel at both N-terminus and C-terminus, which is distinct to those of the other two major envelope proteins VP28 and VP26. Structural comparison of VP24 with VP26 and VP28 reveals opposite electrostatic surface potential properties of them. These structural differences could provide insight into their differential functional mechanisms and roles for virus assembly and infection. Moreover, the structure reveals a trimeric assembly, suggesting a likely natural conformation of VP24 in viral envelope. Therefore, in addition to confirming the evolutionary relationship among the three abundant envelope proteins of WSSV, our structural studies also facilitate a better understanding of the molecular mechanism underlying special roles of VP24 in WSSV assembly and infection.

 

<div class="pdbe-citations 5hlj" style="background-color:#fffaf0;"></div>

== References ==

[[Category: Fu, Z Q]]

[[Category: Su, Y T]]

[[Category: Sun, L F]]

[[Category: Wu, Y K]]

[[Category: Zhao, Y H]]

[[Category: Envelope protein]]

[[Category: Viral protein]]

[[Category: Wssv]]