4z4q

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==Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae==
==Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae==
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<StructureSection load='4z4q' size='340' side='right' caption='[[4z4q]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
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<StructureSection load='4z4q' size='340' side='right'caption='[[4z4q]], [[Resolution|resolution]] 3.04&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4z4q]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z4Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Z4Q FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4z4q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4] and [https://en.wikipedia.org/wiki/PBR322_based_IG-lambda_expression_vector PBR322 based IG-lambda expression vector]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z4Q FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDQ:3-AMINO-7-{(3R)-3-[(1S)-1-AMINOETHYL]PYRROLIDIN-1-YL}-1-CYCLOPROPYL-6-FLUORO-8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE'>PDQ</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.04&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4koe|4koe]], [[4pxp|4pxp]], [[3rad|3rad]], [[3rae|3rae]], [[3raf|3raf]], [[3ksb|3ksb]], [[3ksa|3ksa]], [[4i3h|4i3h]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDQ:3-AMINO-7-{(3R)-3-[(1S)-1-AMINOETHYL]PYRROLIDIN-1-YL}-1-CYCLOPROPYL-6-FLUORO-8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE'>PDQ</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z4q OCA], [http://pdbe.org/4z4q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4z4q RCSB], [http://www.ebi.ac.uk/pdbsum/4z4q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4z4q ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z4q OCA], [https://pdbe.org/4z4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z4q RCSB], [https://www.ebi.ac.uk/pdbsum/4z4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z4q ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN]] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
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[https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [https://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref>
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==See Also==
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*[[Topoisomerase 3D structures|Topoisomerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Crevel, I M.T]]
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[[Category: Large Structures]]
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[[Category: Fisher, L M]]
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[[Category: PBR322 based IG-lambda expression vector]]
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[[Category: Laponogov, I]]
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[[Category: Streptococcus pneumoniae TIGR4]]
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[[Category: Pan, X S]]
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[[Category: Crevel IM-T]]
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[[Category: Sanderson, M R]]
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[[Category: Fisher LM]]
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[[Category: Selvarajah, J]]
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[[Category: Laponogov I]]
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[[Category: Veselkov, D A]]
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[[Category: Pan X-S]]
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[[Category: Cleavage complex]]
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[[Category: Sanderson MR]]
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[[Category: Dna]]
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[[Category: Selvarajah J]]
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[[Category: Isomerase]]
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[[Category: Veselkov DA]]
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[[Category: Quinolone]]
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[[Category: Topoisomerase iv]]
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Current revision

Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae

PDB ID 4z4q

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