5b7w

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==Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv.campestris==
==Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv.campestris==
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<StructureSection load='5b7w' size='340' side='right' caption='[[5b7w]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
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<StructureSection load='5b7w' size='340' side='right'caption='[[5b7w]], [[Resolution|resolution]] 2.08&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5b7w]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5B7W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5b7w]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_campestris_pv._campestris_str._8004 Xanthomonas campestris pv. campestris str. 8004]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5B7W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5B7W FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [http://pdbe.org/5b7w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [http://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5b7w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5b7w OCA], [https://pdbe.org/5b7w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5b7w RCSB], [https://www.ebi.ac.uk/pdbsum/5b7w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5b7w ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Y3703_XANC8 Y3703_XANC8]
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As an important bacterial second messenger, bis-(3',5')-cyclic diguanylate (cyclic di-GMP or c-di-GMP) has been implicated in numerous biological activities, including biofilm formation, motility, survival and virulence. These processes are manipulated by the binding of c-di-GMP to its receptors. XC_3703 from the plant pathogen Xanthomonas campestris pv. campestris, which belongs to the YajQ family of proteins, has recently been identified as a potential c-di-GMP receptor. XC_3703, together with XC_2801, functions as a transcription factor activating virulence-related genes, which can be reversed by the binding of c-di-GMP to XC_3703. However, the structural basis of how c-di-GMP regulates XC_3703 remains elusive. In this study, the structure of XC_3703 was determined to 2.1 A resolution using the molecular-replacement method. The structure of XC_3703 consists of two domains adopting the same topology, which is similar to that of the RNA-recognition motif (RRM). Arg65, which is conserved among the c-di-GMP-binding subfamily of the YajQ family of proteins, together with Phe80 in domain II, forms a putative c-di-GMP binding site.
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Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv. campestris.,Zhao Z, Wu Z, Zhang J Acta Crystallogr F Struct Biol Commun. 2016 Sep;72(Pt 9):720-5. doi:, 10.1107/S2053230X16013017. Epub 2016 Aug 26. PMID:27599864<ref>PMID:27599864</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5b7w" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Wu, Z]]
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[[Category: Large Structures]]
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[[Category: Zhao, Z]]
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[[Category: Xanthomonas campestris pv. campestris str. 8004]]
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[[Category: Receptor]]
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[[Category: Wu Z]]
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[[Category: Unknown function]]
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[[Category: Zhao Z]]

Current revision

Crystal structure of the YajQ-family protein XC_3703 from Xanthomonas campestris pv.campestris

PDB ID 5b7w

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