5keb

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==mouse Klf4 ZnF1-3 (E446D) and CpG/CpG sequence DNA complex structure: Form II==
==mouse Klf4 ZnF1-3 (E446D) and CpG/CpG sequence DNA complex structure: Form II==
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<StructureSection load='5keb' size='340' side='right' caption='[[5keb]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
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<StructureSection load='5keb' size='340' side='right'caption='[[5keb]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5keb]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KEB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5keb]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KEB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KEB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.453&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ke6|5ke6]], [[5ke7|5ke7]], [[5ke8|5ke8]], [[5ke9|5ke9]], [[5kea|5kea]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5keb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5keb OCA], [http://pdbe.org/5keb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5keb RCSB], [http://www.ebi.ac.uk/pdbsum/5keb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5keb ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5keb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5keb OCA], [https://pdbe.org/5keb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5keb RCSB], [https://www.ebi.ac.uk/pdbsum/5keb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5keb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE]] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>
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[https://www.uniprot.org/uniprot/KLF4_MOUSE KLF4_MOUSE] Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription (By similarity).<ref>PMID:10556311</ref> <ref>PMID:10431239</ref> <ref>PMID:15358627</ref> <ref>PMID:16954384</ref> <ref>PMID:17060454</ref> <ref>PMID:19816951</ref> <ref>PMID:20071344</ref>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cheng, X]]
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[[Category: Large Structures]]
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[[Category: Hashimoto, H]]
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[[Category: Mus musculus]]
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[[Category: Klf4]]
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[[Category: Synthetic construct]]
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[[Category: Kruppel-like factor]]
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[[Category: Cheng X]]
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[[Category: Transcription factor-dna complex]]
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[[Category: Hashimoto H]]
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[[Category: Zinc finger]]
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Current revision

mouse Klf4 ZnF1-3 (E446D) and CpG/CpG sequence DNA complex structure: Form II

PDB ID 5keb

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