5gph
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution structure of the Pin1-PPIase (S138A) mutant== | |
| + | <StructureSection load='5gph' size='340' side='right'caption='[[5gph]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5gph]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GPH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GPH FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gph OCA], [https://pdbe.org/5gph PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gph RCSB], [https://www.ebi.ac.uk/pdbsum/5gph PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gph ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIN1_HUMAN PIN1_HUMAN] Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation.<ref>PMID:15664191</ref> <ref>PMID:16644721</ref> <ref>PMID:21497122</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Peptidyl-prolyl cis-trans isomerase 3D structures|Peptidyl-prolyl cis-trans isomerase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tate S]] | ||
| + | [[Category: Tochio N]] | ||
| + | [[Category: Wang J]] | ||
Current revision
Solution structure of the Pin1-PPIase (S138A) mutant
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