5t9u
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5t9u is ON HOLD Authors: Appleby, T.C., Steadman, V., Pettit, S., Schmitz, U., Mackman, R.L., Schultz, B. Description: Discovery of a Potent Cyclop...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A== | |
| + | <StructureSection load='5t9u' size='340' side='right'caption='[[5t9u]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5t9u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T9U FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.301Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7HG:3-[(3-HYDROXYPHENYL)METHYL]-10,12-DIMETHOXY-9,11-DIMETHYL-6-(PROPAN-2-YL)-19-OXA-1,4,7,25-TETRAAZABICYCLO[19.3.1]PENTACOSA-13,15-DIENE-2,5,8,20-TETRONE'>7HG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t9u OCA], [https://pdbe.org/5t9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t9u RCSB], [https://www.ebi.ac.uk/pdbsum/5t9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t9u ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPIA_HUMAN PPIA_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. | ||
| - | + | ==See Also== | |
| - | + | *[[Cyclophilin 3D structures|Cyclophilin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Mackman | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Appleby TC]] |
| - | [[Category: | + | [[Category: Mackman RL]] |
| - | [[Category: Schultz | + | [[Category: Pettit S]] |
| - | [[Category: Steadman | + | [[Category: Schmitz U]] |
| + | [[Category: Schultz B]] | ||
| + | [[Category: Steadman V]] | ||
Current revision
Discovery of a Potent Cyclophilin Inhibitor (Compound 3) based on Structural Simplification of Sanglifehrin A
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