This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5i59

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:23, 23 August 2023) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007==
==Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007==
-
<StructureSection load='5i59' size='340' side='right' caption='[[5i59]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
+
<StructureSection load='5i59' size='340' side='right'caption='[[5i59]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5i59]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I59 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I59 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5i59]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I59 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I59 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=67Q:5-({[(3,4-DIFLUOROPHENYL)SULFONYL]AMINO}METHYL)-6-METHYL-N-[(2-METHYL-4H-1LAMBDA~4~,3-THIAZOL-5-YL)METHYL]PYRAZINE-2-CARBOXAMIDE'>67Q</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5i57|5i57]], [[5i56|5i56]], [[5i58|5i58]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=67Q:5-({[(3,4-DIFLUOROPHENYL)SULFONYL]AMINO}METHYL)-6-METHYL-N-[(2-METHYL-4H-1LAMBDA~4~,3-THIAZOL-5-YL)METHYL]PYRAZINE-2-CARBOXAMIDE'>67Q</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i59 OCA], [http://pdbe.org/5i59 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i59 RCSB], [http://www.ebi.ac.uk/pdbsum/5i59 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i59 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i59 OCA], [https://pdbe.org/5i59 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i59 RCSB], [https://www.ebi.ac.uk/pdbsum/5i59 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i59 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref> [[http://www.uniprot.org/uniprot/NMDE1_RAT NMDE1_RAT]] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits.
+
[https://www.uniprot.org/uniprot/NMDZ1_RAT NMDZ1_RAT] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors.<ref>PMID:15996549</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 5i59" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5i59" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Hansen, K B]]
+
[[Category: Large Structures]]
-
[[Category: Mou, T C]]
+
[[Category: Rattus norvegicus]]
-
[[Category: Sprang, S R]]
+
[[Category: Hansen KB]]
-
[[Category: Antagonist]]
+
[[Category: Mou T-C]]
-
[[Category: Nmda receptor]]
+
[[Category: Sprang SR]]
-
[[Category: Receptor]]
+
-
[[Category: Transport protein]]
+

Current revision

Glutamate- and glycine-bound GluN1/GluN2A agonist binding domains with MPX 007

PDB ID 5i59

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5i59"
Personal tools