5ilp

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==H64Q sperm whale myoglobin with a Fe-tolyl moiety==
==H64Q sperm whale myoglobin with a Fe-tolyl moiety==
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<StructureSection load='5ilp' size='340' side='right' caption='[[5ilp]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
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<StructureSection load='5ilp' size='340' side='right'caption='[[5ilp]], [[Resolution|resolution]] 1.88&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ilp]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ILP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ILP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ilp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Physeter_catodon Physeter catodon]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ILP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ILP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6CQ:[3,3-(7,12-DIETHENYL-3,8,13,17-TETRAMETHYLPORPHYRIN-2,18-DIYL-KAPPA~4~N~21~,N~22~,N~23~,N~24~)DI(PROPANOATO)(2-)](3-METHYLPHENYL)IRON'>6CQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iks|5iks]], [[5ilr|5ilr]], [[5ile|5ile]], [[5ilm|5ilm]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6CQ:[3,3-(7,12-DIETHENYL-3,8,13,17-TETRAMETHYLPORPHYRIN-2,18-DIYL-KAPPA~4~N~21~,N~22~,N~23~,N~24~)DI(PROPANOATO)(2-)](3-METHYLPHENYL)IRON'>6CQ</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ilp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ilp OCA], [http://pdbe.org/5ilp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ilp RCSB], [http://www.ebi.ac.uk/pdbsum/5ilp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ilp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ilp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ilp OCA], [https://pdbe.org/5ilp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ilp RCSB], [https://www.ebi.ac.uk/pdbsum/5ilp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ilp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MYG_PHYCD MYG_PHYCD]] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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[https://www.uniprot.org/uniprot/MYG_PHYMC MYG_PHYMC] Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Bioorganometallic Fe-C bonds are biologically relevant species that may result from the metabolism of natural or synthetic hydrazines. The molecular structures of four new sperm whale mutant myoglobin derivatives with Fe-aryl moieties, namely H64A-tolyl-m, H64A-chlorophenyl-p, H64Q-tolyl-m, and H64Q-chlorophenyl-p, have been determined at 1.7-1.9A resolution. The structures reveal conformational preferences for the substituted aryls resulting from attachment of the aryl ligands to Fe at the site of net -NHNH2 release from the precursor hydrazines, and show distal pocket changes that readily accommodate these bulky ligands.
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Organometallic myoglobins: Formation of Fe-carbon bonds and distal pocket effects on aryl ligand conformations.,Wang B, Thomas LM, Richter-Addo GB J Inorg Biochem. 2016 Jun 24. pii: S0162-0134(16)30192-1. doi:, 10.1016/j.jinorgbio.2016.06.028. PMID:27687333<ref>PMID:27687333</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5ilp" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Myoglobin 3D structures|Myoglobin 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Richter-Addo, G B]]
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[[Category: Large Structures]]
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[[Category: Thomas, L M]]
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[[Category: Physeter catodon]]
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[[Category: Wang, B]]
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[[Category: Richter-Addo GB]]
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[[Category: 3-methylphenylhydrazine]]
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[[Category: Thomas LM]]
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[[Category: 4-chlorophenylhydrazine]]
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[[Category: Wang B]]
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[[Category: Arylhydrazine]]
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[[Category: Bioorganometallic]]
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[[Category: Heme]]
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[[Category: Hydrazine]]
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[[Category: Iron-carbon]]
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[[Category: Meta-tolylhydrazine]]
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[[Category: Myoglobin]]
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[[Category: Oxygen transport]]
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[[Category: Para-chlorophenylhydrazine]]
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[[Category: Phenylhydrazine]]
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[[Category: Sigma-aryl]]
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Current revision

H64Q sperm whale myoglobin with a Fe-tolyl moiety

PDB ID 5ilp

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