TRNA methyltransferase
From Proteopedia
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| - | <StructureSection load=' | + | <StructureSection load='' size='350' side='right' caption='Structure of tRNA methyltransferase for N1 of guanine 37 complex with S-adenosylhomocysteine (PDB entry [[1uak]])' scene='55/553109/Cv/1'> |
| + | __TOC__ | ||
== Function == | == Function == | ||
| - | '''tRNA methyltransferase''' (Trm) methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH)<ref>PMID:25626150</ref>. S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction. | + | '''tRNA methyltransferase''' ('''Trm''') methylates specific positions on tRNA. tRNA methylation is a post-transcription modification. The methyl donor is S-adenosylmethionine (SAM) and the product is the methylated tRNA and S-adenosylhomocysteine (SAH)<ref>PMID:25626150</ref>. S-adenosylornithine or sinefugin (SFG) is an inhibitor of the reaction. |
For details on Trm to N2 of guanine 6 see [[TRNA:m2G6 methyltransferase TrmN/Trm14]]. | For details on Trm to N2 of guanine 6 see [[TRNA:m2G6 methyltransferase TrmN/Trm14]]. | ||
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| + | *'''Dual specificity tRNA methyltransferase Rlmn''' is an ''E. coli'' methyltransferase which modifies both ribosomal 23S RNA and tRNA<ref>PMID:22891362</ref>. | ||
| + | *'''METTL6''' modifies cytidine 32<ref>PMId:32923617</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
| - | Trm active site is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. | + | Trm <scene name='55/553109/Cv/4'>active site</scene> is located at the cleft at the subunit interface<ref>PMID:12773376</ref>. Water molecules are shown as red spheres. |
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==3D structures of tRNA methyltransferase== | ==3D structures of tRNA methyltransferase== | ||
| + | [[tRNA methyltransferase 3D structures]] | ||
| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
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| - | *'''tRNA guanine 9 N1 methyltransferase''' | ||
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| - | **[[4jwg]] – fyTrm – fission yeast<br /> | ||
| - | **[[4jwf]], [[4jwh]] – fyTrm + SAH <br /> | ||
| - | **[[4jwj]] – yTrm + SAH – yeast<br /> | ||
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| - | *'''tRNA guanine 37 N1 methyltransferase''' | ||
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| - | **[[3knu]] – ApTrm – ''Anaplasma phagocytophilum'' <br /> | ||
| - | **[[1oy5]] – AaTrm – ''Aquifex aeolicus'' <br /> | ||
| - | **[[3ief]] – Trm – ''Bartonella henselae'' <br /> | ||
| - | **[[1uaj]] – HiTrm – ''haemophilus influenzae''<br /> | ||
| - | **[[3ky7]] – Trm – ''Staphylococcus aureus''<br /> | ||
| - | **[[3quv]] – Trm – ''Mycobacterium abscessus''<br /> | ||
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| - | *Complexes of tRNA guanine 37 N1 methyltransferase | ||
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| - | **[[1uak]] – HiTrm + SAM <br /> | ||
| - | **[[1ual]], [[1uam]] – HiTrm + SAH <br /> | ||
| - | **[[3axz]] – HiTrm + adenosine<br /> | ||
| - | **[[4mcb]], [[4mcc]], [[4mcd]] – HiTrm + inhibitor<br /> | ||
| - | **[[1p9p]] – EcTrm + SAH – ''Escherichia coli'' <br /> | ||
| - | **[[2yx1]] – MjTrm + SFG – ''Methanocalcococcus jannaschii''<br /> | ||
| - | **[[3ay0]] – MjTrm + adenosine<br /> | ||
| - | **[[4h3y]], [[4h3z]] – Trm + SAH – ''Burkholderia phymatum'' <br /> | ||
| - | **[[4ig6]] – ApTrm + SAH <br /> | ||
| - | **[[4gek]], [[4iwn]] – EcTrm + SAM derivative<br /> | ||
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| - | *'''tRNA guanine 46 N7 methyltransferase''' | ||
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| - | **[[1yzh]] – Trm – ''Streptococcus pneumoniae'' <br /> | ||
| - | **[[2fca]] – Trm – ''Bacillus subtilis'' <br /> | ||
| - | **[[2vdu]], [[2vdv]] – yTrm <br /> | ||
| - | **[[3dxx]] – EcTrm <br /> | ||
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| - | *Complexes of tRNA guanine 46 N7 methyltransferase | ||
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| - | **[[3ckk]] – Trm + SAM - human<br /> | ||
| - | **[[3dxy]] – EcTrm + SAM <br /> | ||
| - | **[[3dxz]] – EcTrm + SAH <br /> | ||
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| - | *'''tRNA cytidine 34 O2 methyltransferase''' | ||
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| - | **[[3e5y]] – BpTrm – ''Burkholderia pseudomalllei'' <br /> | ||
| - | **[[4jak]], [[4kdz]] – EcTrm <br /> | ||
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| - | *Complexes of tRNA cytidine 34 O2 methyltransferase | ||
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| - | **[[4kgn]] – BpTrm + SAH <br /> | ||
| - | **[[3n4k]], [[3n4j]] – Trm + SAH – ''Yersinia pestis'' <br /> | ||
| - | **[[1mxi]], [[1im8]] – HiTrm + SAH <br /> | ||
| - | **[[4jal]] – EcTrm + SAH<br /> | ||
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| - | *'''tRNA guanine 6 N2 methyltransferase''' | ||
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| - | **[[3tm5]] – PfTrm + SFG – ''Pyrococcvus furiosus''<br /> | ||
| - | **[[3tlj]] – PfTrm + SAH<br /> | ||
| - | **[[3tm4]] – PfTrm + SAM<br /> | ||
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| - | *'''tRNA adenine N1 methyltransferase''' | ||
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| - | **[[2pwy]] – Trm – ''Thermos thermophilus''<br /> | ||
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| - | *'''tRNA uracil 54 methyltransferase''' | ||
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| - | **[[3bt7]] – yTrm + RNA<br /> | ||
| - | }} | ||
== References == | == References == | ||
<references/> | <references/> | ||
| + | </StructureSection> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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