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| - | [[Image:1p1y.gif|left|200px]] | |
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| - | {{Structure
| + | ==Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)== |
| - | |PDB= 1p1y |SIZE=350|CAPTION= <scene name='initialview01'>1p1y</scene>, resolution 2.10Å
| + | <StructureSection load='1p1y' size='340' side='right'caption='[[1p1y]], [[Resolution|resolution]] 2.10Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND= <scene name='pdbligand=BRU:5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=CB2:PHOSPHORIC+ACID+MONO-[5-(4-AMINO-5-BROMO-2-OXO-2H-PYRIMIDIN-1-YL)-3,4-DIHYDROXY-TETRAHYDRO-FURAN-2-YLMETHYL]+ESTER'>CB2</scene>, <scene name='pdbligand=DA:2'-DEOXYADENOSINE-5'-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
| + | <table><tr><td colspan='2'>[[1p1y]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P1Y FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | |GENE=
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BRU:5-BROMO-2-DEOXYURIDINE-5-MONOPHOSPHATE'>BRU</scene>, <scene name='pdbligand=CBR:5-BROMO-2-DEOXY-CYTIDINE-5-MONOPHOSPHATE'>CBR</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | |DOMAIN=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p1y OCA], [https://pdbe.org/1p1y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p1y RCSB], [https://www.ebi.ac.uk/pdbsum/1p1y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p1y ProSAT]</span></td></tr> |
| - | |RELATEDENTRY=
| + | </table> |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p1y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p1y OCA], [http://www.ebi.ac.uk/pdbsum/1p1y PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p1y RCSB]</span>
| + | __TOC__ |
| - | }}
| + | </StructureSection> |
| - | | + | [[Category: Large Structures]] |
| - | '''Crystal structure of a continuous three-dimensional DNA lattice from d(GGACAGATGGGAG)'''
| + | [[Category: Birktoft JJ]] |
| - | | + | [[Category: Nowakowski J]] |
| - | | + | [[Category: Paukstelis PJ]] |
| - | ==Overview==
| + | [[Category: Seeman NC]] |
| - | DNA has proved to be a versatile material for the rational design and assembly of nanometer scale objects. Here we report the crystal structure of a continuous three-dimensional DNA lattice formed by the self-assembly of a DNA 13-mer. The structure consists of stacked layers of parallel helices with adjacent layers linked through parallel-stranded base pairing. The hexagonal lattice geometry contains solvent channels that appear large enough to allow 3'-linked guest molecules into the crystal. We have successfully used these parallel base pairs to design and produce crystals with greatly enlarged solvent channels. This lattice may have applications as a molecular scaffold for structure determination of guest molecules, as a molecular sieve, or in the assembly of molecular electronics. Predictable non-Watson-Crick base pairs, like those described here, may present a new tool in structural DNA nanotechnology.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1P1Y is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P1Y OCA].
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| - | | + | |
| - | ==Reference==
| + | |
| - | Crystal structure of a continuous three-dimensional DNA lattice., Paukstelis PJ, Nowakowski J, Birktoft JJ, Seeman NC, Chem Biol. 2004 Aug;11(8):1119-26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15324813 15324813]
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| - | [[Category: Protein complex]] | + | |
| - | [[Category: Birktoft, J J.]] | + | |
| - | [[Category: Nowakowski, J.]] | + | |
| - | [[Category: Paukstelis, P J.]] | + | |
| - | [[Category: Seeman, N C.]] | + | |
| - | [[Category: continuous three-dimensional dna lattice]]
| + | |
| - | [[Category: parallel-stranded base pair]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:53:39 2008''
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