Sandbox 10002

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Current revision (15:25, 14 January 2017) (edit) (undo)
 
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==Your Heading Here (maybe something like 'Structure')== 0
==Your Heading Here (maybe something like 'Structure')== 0
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<StructureSection load='1acj' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1tup' size='340' side='right' caption='P53 bound to DNA' scene='74/743160/Initl/5'>
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[[1ACJ]]* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
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[[1TUP]] shows the crystal structure of p53 (DNA binding domain) with DNA.
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Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease.
 
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Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330.
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P53 (DNA Binding Domain) bound to DNA
== Function ==
== Function ==
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<scene name='74/743160/Tha_at_active_site/1'>Tacrine sandwiched between F330 and W84</scene>
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== Disease ==
== Disease ==
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== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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<scene name='74/743160/Initl/5'>p53 (DNA Binding Domain) bound to DNA (Y/Y)</scene>
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<scene name='74/743160/Initl/2'>R248</scene>
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<scene name='74/743160/Initl/6'>175,24,9,273,282,245</scene>
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

==Your Heading Here (maybe something like 'Structure')== 0

P53 bound to DNA

Drag the structure with the mouse to rotate

References

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