We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

5a7c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:04, 10 January 2024) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 1: Line 1:
==Crystal structure of the second bromodomain of human BRD3 in complex with compound==
==Crystal structure of the second bromodomain of human BRD3 in complex with compound==
-
<StructureSection load='5a7c' size='340' side='right' caption='[[5a7c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+
<StructureSection load='5a7c' size='340' side='right'caption='[[5a7c]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5a7c]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A7C FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5a7c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A7C FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5D4:N-(6-ACETAMIDOHEXYL)ACETAMIDE'>5D4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a6n|5a6n]], [[5a6o|5a6o]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5D4:N-(6-ACETAMIDOHEXYL)ACETAMIDE'>5D4</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a7c OCA], [http://pdbe.org/5a7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a7c RCSB], [http://www.ebi.ac.uk/pdbsum/5a7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a7c ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a7c OCA], [https://pdbe.org/5a7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a7c RCSB], [https://www.ebi.ac.uk/pdbsum/5a7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a7c ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
-
[[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
+
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN]] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>
+
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 21: Line 21:
</div>
</div>
<div class="pdbe-citations 5a7c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5a7c" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Diehl, C]]
+
[[Category: Homo sapiens]]
-
[[Category: Hakansson, M]]
+
[[Category: Large Structures]]
-
[[Category: Kimbung, R]]
+
[[Category: Diehl C]]
-
[[Category: Logan, D T]]
+
[[Category: Hakansson M]]
-
[[Category: Walse, B]]
+
[[Category: Kimbung R]]
-
[[Category: Welin, M]]
+
[[Category: Logan DT]]
-
[[Category: Brd3]]
+
[[Category: Walse B]]
-
[[Category: Brd3 domain 2]]
+
[[Category: Welin M]]
-
[[Category: Bromodomain containing protein 3]]
+
-
[[Category: Dna binding protein]]
+
-
[[Category: Ring3-like protein]]
+

Current revision

Crystal structure of the second bromodomain of human BRD3 in complex with compound

PDB ID 5a7c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5a7c"
Personal tools