5tdh

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m (Protected "5tdh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5tdh is ON HOLD
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==The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S==
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<StructureSection load='5tdh' size='340' side='right'caption='[[5tdh]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5tdh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TDH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tdh OCA], [https://pdbe.org/5tdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tdh RCSB], [https://www.ebi.ac.uk/pdbsum/5tdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tdh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
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Authors: Liu, P., Jai, M.-Z., Zhou, X.E., de Waal, P.W., Dickson, B.M., Liu, B., Hou, L., Yin, Y.-T., Kang, Y.-Y., Shi, Y., Melcher, K., Xu, H.E., Jiang, Y.
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==See Also==
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*[[Transducin 3D structures|Transducin 3D structures]]
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Description: The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Zhou, X.E]]
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__TOC__
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[[Category: Xu, H.E]]
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</StructureSection>
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[[Category: Melcher, K]]
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[[Category: Bos taurus]]
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[[Category: Kang, Y.-Y]]
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[[Category: Homo sapiens]]
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[[Category: Jiang, Y]]
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[[Category: Large Structures]]
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[[Category: Liu, P]]
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[[Category: Rattus norvegicus]]
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[[Category: Dickson, B.M]]
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[[Category: Dickson BM]]
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[[Category: Jai, M.-Z]]
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[[Category: Hou L]]
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[[Category: Yin, Y.-T]]
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[[Category: Jia M-Z]]
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[[Category: Shi, Y]]
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[[Category: Jiang Y]]
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[[Category: Hou, L]]
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[[Category: Kang Y-Y]]
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[[Category: Liu, B]]
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[[Category: Liu B]]
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[[Category: De Waal, P.W]]
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[[Category: Liu P]]
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[[Category: Melcher K]]
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[[Category: Shi Y]]
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[[Category: Xu HE]]
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[[Category: Yin Y-T]]
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[[Category: Zhou XE]]
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[[Category: De Waal PW]]

Current revision

The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S

PDB ID 5tdh

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