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5tdh
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S== |
| + | <StructureSection load='5tdh' size='340' side='right'caption='[[5tdh]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5tdh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TDH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TDH FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tdh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tdh OCA], [https://pdbe.org/5tdh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tdh RCSB], [https://www.ebi.ac.uk/pdbsum/5tdh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tdh ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Transducin 3D structures|Transducin 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Jiang | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Dickson BM]] |
| - | [[Category: | + | [[Category: Hou L]] |
| - | [[Category: | + | [[Category: Jia M-Z]] |
| - | [[Category: Shi | + | [[Category: Jiang Y]] |
| - | [[Category: | + | [[Category: Kang Y-Y]] |
| - | [[Category: | + | [[Category: Liu B]] |
| - | [[Category: De Waal | + | [[Category: Liu P]] |
| + | [[Category: Melcher K]] | ||
| + | [[Category: Shi Y]] | ||
| + | [[Category: Xu HE]] | ||
| + | [[Category: Yin Y-T]] | ||
| + | [[Category: Zhou XE]] | ||
| + | [[Category: De Waal PW]] | ||
Current revision
The crystal structure of the dominant negative mutant G protein alpha(i)-1-beta-1-gamma-2 G203A/A326S
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Categories: Bos taurus | Homo sapiens | Large Structures | Rattus norvegicus | Dickson BM | Hou L | Jia M-Z | Jiang Y | Kang Y-Y | Liu B | Liu P | Melcher K | Shi Y | Xu HE | Yin Y-T | Zhou XE | De Waal PW
