5jxc

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==SynGAP Coiled-coil trimer==
==SynGAP Coiled-coil trimer==
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<StructureSection load='5jxc' size='340' side='right' caption='[[5jxc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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<StructureSection load='5jxc' size='340' side='right'caption='[[5jxc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jxc]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JXC FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jxc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JXC FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5jxb|5jxb]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxc OCA], [http://pdbe.org/5jxc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jxc RCSB], [http://www.ebi.ac.uk/pdbsum/5jxc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxc ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jxc OCA], [https://pdbe.org/5jxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jxc RCSB], [https://www.ebi.ac.uk/pdbsum/5jxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jxc ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/SYGP1_MOUSE SYGP1_MOUSE] Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits (By similarity).
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Postsynaptic densities (PSDs) are membrane semi-enclosed, submicron protein-enriched cellular compartments beneath postsynaptic membranes, which constantly exchange their components with bulk aqueous cytoplasm in synaptic spines. Formation and activity-dependent modulation of PSDs is considered as one of the most basic molecular events governing synaptic plasticity in the nervous system. In this study, we discover that SynGAP, one of the most abundant PSD proteins and a Ras/Rap GTPase activator, forms a homo-trimer and binds to multiple copies of PSD-95. Binding of SynGAP to PSD-95 induces phase separation of the complex, forming highly concentrated liquid-like droplets reminiscent of the PSD. The multivalent nature of the SynGAP/PSD-95 complex is critical for the phase separation to occur and for proper activity-dependent SynGAP dispersions from the PSD. In addition to revealing a dynamic anchoring mechanism of SynGAP at the PSD, our results also suggest a model for phase-transition-mediated formation of PSD.
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Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.,Zeng M, Shang Y, Araki Y, Guo T, Huganir RL, Zhang M Cell. 2016 Aug 25;166(5):1163-1175.e12. doi: 10.1016/j.cell.2016.07.008. PMID:27565345<ref>PMID:27565345</ref>
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==See Also==
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*[[Ras GTPase activating protein|Ras GTPase activating protein]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 5jxc" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Shang, Y]]
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[[Category: Large Structures]]
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[[Category: Zhang, M]]
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[[Category: Mus musculus]]
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[[Category: Coiled-coil]]
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[[Category: Shang Y]]
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[[Category: Signaling protein]]
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[[Category: Zhang M]]
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[[Category: Syngap]]
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[[Category: Trimer]]
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SynGAP Coiled-coil trimer

PDB ID 5jxc

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