5j5c

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==Crystal structure of ARL1-GTP and DCB domain of BIG1 complex==
==Crystal structure of ARL1-GTP and DCB domain of BIG1 complex==
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<StructureSection load='5j5c' size='340' side='right' caption='[[5j5c]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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<StructureSection load='5j5c' size='340' side='right'caption='[[5j5c]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j5c]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J5C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J5C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j5c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J5C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j5c OCA], [http://pdbe.org/5j5c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j5c RCSB], [http://www.ebi.ac.uk/pdbsum/5j5c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j5c ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j5c OCA], [https://pdbe.org/5j5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j5c RCSB], [https://www.ebi.ac.uk/pdbsum/5j5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j5c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ARL1_HUMAN ARL1_HUMAN]] GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.<ref>PMID:9624189</ref> [[http://www.uniprot.org/uniprot/BIG1_HUMAN BIG1_HUMAN]] Promotes guanine-nucleotide exchange on ARF1 and ARF3. Promotes the activation of ARF1/ARF3 through replacement of GDP with GTP. Involved in vesicular trafficking. Required for the maintenance of Golgi structure; the function may be independent of its GEF activity. Required for the maturaion of integrin beta-1 in the Golgi. Involved in the establishment and persistence of cell polarity during directed cell movement in wound healing. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways. Inhibits GAP activity of MYO9B probably through competetive RhoA binding. The function in the nucleus remains to be determined.<ref>PMID:12571360</ref> <ref>PMID:15644318</ref> <ref>PMID:17227842</ref> <ref>PMID:22084092</ref> <ref>PMID:20360857</ref>
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[https://www.uniprot.org/uniprot/ARL1_HUMAN ARL1_HUMAN] GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.<ref>PMID:9624189</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ding, J]]
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[[Category: Homo sapiens]]
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[[Category: Wang, R]]
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[[Category: Large Structures]]
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[[Category: Wang, Z]]
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[[Category: Ding J]]
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[[Category: Zhang, T]]
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[[Category: Wang R]]
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[[Category: Effector]]
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[[Category: Wang Z]]
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[[Category: Gef]]
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[[Category: Zhang T]]
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[[Category: Signaling protein]]
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[[Category: Small gtpase]]
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Current revision

Crystal structure of ARL1-GTP and DCB domain of BIG1 complex

PDB ID 5j5c

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