5l1c
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Heteronuclear Solution Structure of Chlorotoxin== | |
| - | + | <StructureSection load='5l1c' size='340' side='right'caption='[[5l1c]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leiurus_quinquestriatus_quinquestriatus Leiurus quinquestriatus quinquestriatus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L1C FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l1c OCA], [https://pdbe.org/5l1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l1c RCSB], [https://www.ebi.ac.uk/pdbsum/5l1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l1c ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CTXL_LEIQU CTXL_LEIQU] This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).<ref>PMID:12454020</ref> <ref>PMID:16520829</ref> <ref>PMID:8383429</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Leiurus quinquestriatus quinquestriatus]] | ||
| + | [[Category: Braga CB]] | ||
| + | [[Category: Mobli M]] | ||
| + | [[Category: Sharma G]] | ||
Current revision
Heteronuclear Solution Structure of Chlorotoxin
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