5lyf
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5lyf is ON HOLD until Paper Publication Authors: Schreuder, H., Liesum, A., Loenze, P. Description: Crystal structure of 1 in complex with tafCPB [...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of 1 in complex with tafCPB== | |
| + | <StructureSection load='5lyf' size='340' side='right'caption='[[5lyf]], [[Resolution|resolution]] 2.01Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5lyf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LYF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5LYF FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7B6:(2~{S})-6-AZANYL-2-[[(2~{R})-1-[[(1~{R},2~{S},4~{S})-2-BICYCLO[2.2.1]HEPTANYL]AMINO]-3-CYCLOHEXYL-1-OXIDANYLIDENE-PROPAN-2-YL]CARBAMOYLAMINO]HEXANOIC+ACID'>7B6</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5lyf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lyf OCA], [https://pdbe.org/5lyf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5lyf RCSB], [https://www.ebi.ac.uk/pdbsum/5lyf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5lyf ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CBPB1_PIG CBPB1_PIG] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Previously disclosed TAFIa inhibitors having a urea zinc-binding motif were used as the starting point for the development of a novel class of highly potent inhibitors having a sulfamide zinc-binding motif. High-resolution X-ray cocrystal structures were used to optimize the structures and reveal a highly unusual sulfamide configuration. A selected sulfamide was profiled in vitro and in vivo and displayed a promising ADMET profile. | ||
| - | + | Sulfamide as Zinc Binding Motif in Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa).,Halland N, Czech J, Czechtizky W, Evers A, Follmann M, Kohlmann M, Schreuder HA, Kallus C J Med Chem. 2016 Oct 17. PMID:27749053<ref>PMID:27749053</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5lyf" style="background-color:#fffaf0;"></div> |
| - | [[Category: Liesum | + | |
| - | [[Category: Schreuder | + | ==See Also== |
| + | *[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Liesum A]] | ||
| + | [[Category: Loenze P]] | ||
| + | [[Category: Schreuder H]] | ||
Current revision
Crystal structure of 1 in complex with tafCPB
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