1p8f

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[[Image:1p8f.jpg|left|200px]]
 
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{{Structure
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==A four location model to explain the stereospecificity of proteins.==
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|PDB= 1p8f |SIZE=350|CAPTION= <scene name='initialview01'>1p8f</scene>, resolution 1.85&Aring;
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<StructureSection load='1p8f' size='340' side='right'caption='[[1p8f]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ICT:ISOCITRIC+ACID'>ICT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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<table><tr><td colspan='2'>[[1p8f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P8F FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Isocitrate_dehydrogenase_(NADP(+)) Isocitrate dehydrogenase (NADP(+))], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.42 1.1.1.42] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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|GENE= ICD OR ICDA OR ICDE OR B1136 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ICT:ISOCITRIC+ACID'>ICT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8f OCA], [https://pdbe.org/1p8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p8f RCSB], [https://www.ebi.ac.uk/pdbsum/1p8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p8f ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p8f OCA], [http://www.ebi.ac.uk/pdbsum/1p8f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p8f RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/IDH_ECOLI IDH_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p8/1p8f_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p8f ConSurf].
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<div style="clear:both"></div>
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'''A four location model to explain the stereospecificity of proteins.'''
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==See Also==
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*[[Isocitrate dehydrogenase 3D structures|Isocitrate dehydrogenase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1P8F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P8F OCA].
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==Reference==
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A new model for protein stereospecificity., Mesecar AD, Koshland DE Jr, Nature. 2000 Feb 10;403(6770):614-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10688187 10688187]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Isocitrate dehydrogenase (NADP(+))]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Koshland Jr DE]]
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[[Category: Jr., D E.Koshland.]]
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[[Category: Mesecar AD]]
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[[Category: Mesecar, A D.]]
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[[Category: d-isocitrate]]
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[[Category: enantiomer]]
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[[Category: four-location]]
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[[Category: isocitrate dehydrogenase]]
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[[Category: magnesium ion]]
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[[Category: oxidoreductase]]
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[[Category: racemic]]
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[[Category: stereospecificity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:22 2008''
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Current revision

A four location model to explain the stereospecificity of proteins.

PDB ID 1p8f

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