1p9x

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[[Image:1p9x.gif|left|200px]]
 
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{{Structure
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==THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC==
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|PDB= 1p9x |SIZE=350|CAPTION= <scene name='initialview01'>1p9x</scene>, resolution 3.40&Aring;
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<StructureSection load='1p9x' size='340' side='right'caption='[[1p9x]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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<table><tr><td colspan='2'>[[1p9x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P9X FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TEL:TELITHROMYCIN'>TEL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9x OCA], [https://pdbe.org/1p9x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p9x RCSB], [https://www.ebi.ac.uk/pdbsum/1p9x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p9x ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1nkw|1NKW]], [[1njm|1NJM]], [[1njn|1NJN]], [[1jzy|1JZY]], [[1jzx|1JZX]], [[1ond|1OND]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1p9x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p9x OCA], [http://www.ebi.ac.uk/pdbsum/1p9x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1p9x RCSB]</span>
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<div style="background-color:#fffaf0;">
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}}
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== Publication Abstract from PubMed ==
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'''THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC'''
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==Overview==
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The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
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==About this Structure==
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Structural insight into the antibiotic action of telithromycin against resistant mutants.,Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A J Bacteriol. 2003 Jul;185(14):4276-9. PMID:12837804<ref>PMID:12837804</ref>
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1P9X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9X OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Structural insight into the antibiotic action of telithromycin against resistant mutants., Berisio R, Harms J, Schluenzen F, Zarivach R, Hansen HA, Fucini P, Yonath A, J Bacteriol. 2003 Jul;185(14):4276-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12837804 12837804]
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</div>
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<div class="pdbe-citations 1p9x" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Berisio, R.]]
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[[Category: Berisio R]]
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[[Category: Fucini, P.]]
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[[Category: Fucini P]]
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[[Category: Hansen, H A.]]
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[[Category: Hansen HA]]
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[[Category: Harms, J.]]
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[[Category: Harms J]]
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[[Category: Schluenzen, F.]]
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[[Category: Schluenzen F]]
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[[Category: Yonath, A.]]
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[[Category: Yonath A]]
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[[Category: Zarivach, R.]]
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[[Category: Zarivach R]]
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[[Category: antibiotic]]
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[[Category: blockage]]
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[[Category: exit-tunnel]]
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[[Category: ketolide]]
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[[Category: macrolide]]
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[[Category: ribosome]]
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[[Category: trna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:56:56 2008''
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Current revision

THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC

PDB ID 1p9x

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