This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5ik6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:58, 30 August 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Tobacco 5-epi-aristolochene synthase with germacrene A and PPi==
==Tobacco 5-epi-aristolochene synthase with germacrene A and PPi==
-
<StructureSection load='5ik6' size='340' side='right' caption='[[5ik6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
+
<StructureSection load='5ik6' size='340' side='right'caption='[[5ik6]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5ik6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IK6 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5ik6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IK6 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CRE:GERMACRENE+A'>CRE</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ik0|5ik0]], [[5ik9|5ik9]], [[5ika|5ika]], [[5ikh|5ikh]], [[5il3|5il3]], [[5il8|5il8]], [[5ild|5ild]], [[5idh|5idh]], [[5idi|5idi]], [[5idj|5idj]], [[5idk|5idk]], [[5idy|5idy]], [[5idz|5idz]], [[5im1|5im1]]</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CRE:GERMACRENE+A'>CRE</scene>, <scene name='pdbligand=DPO:DIPHOSPHATE'>DPO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-epiaristolochene_synthase 5-epiaristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.61 4.2.3.61] </span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ik6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik6 OCA], [https://pdbe.org/5ik6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ik6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ik6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik6 ProSAT]</span></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ik6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ik6 OCA], [http://pdbe.org/5ik6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ik6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ik6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ik6 ProSAT]</span></td></tr>
+
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
+
[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 24: Line 23:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: 5-epiaristolochene synthase]]
+
[[Category: Large Structures]]
-
[[Category: Bowman, M]]
+
[[Category: Nicotiana tabacum]]
-
[[Category: Koo, H J]]
+
[[Category: Bowman M]]
-
[[Category: Louie, G V]]
+
[[Category: Koo HJ]]
-
[[Category: Noel, J P]]
+
[[Category: Louie GV]]
-
[[Category: Xu, Y]]
+
[[Category: Noel JP]]
-
[[Category: Diphosphate]]
+
[[Category: Xu Y]]
-
[[Category: Germacrene some]]
+
-
[[Category: Lyase]]
+
-
[[Category: Tea]]
+
-
[[Category: Terpene synthase]]
+

Current revision

Tobacco 5-epi-aristolochene synthase with germacrene A and PPi

PDB ID 5ik6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5ik6"
Personal tools