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5ikh

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==Tobacco 5-epi-aristolochene synthase M4 mutant with (-)-premnaspirodiene==
==Tobacco 5-epi-aristolochene synthase M4 mutant with (-)-premnaspirodiene==
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<StructureSection load='5ikh' size='340' side='right' caption='[[5ikh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5ikh' size='340' side='right'caption='[[5ikh]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ikh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IKH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ikh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_tabacum Nicotiana tabacum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IKH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6BW:(2R,5S,10R)-6,10-DIMETHYL-2-(PROP-1-EN-2-YL)SPIRO[4.5]DEC-6-ENE'>6BW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ik0|5ik0]], [[5ik6|5ik6]], [[5ik9|5ik9]], [[5ika|5ika]], [[5il3|5il3]], [[5il8|5il8]], [[5ild|5ild]], [[5ilh|5ilh]], [[5ili|5ili]], [[5ilj|5ilj]], [[5ilk|5ilk]], [[5ily|5ily]], [[5ilz|5ilz]], [[5im1|5im1]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6BW:(2R,5S,10R)-6,10-DIMETHYL-2-(PROP-1-EN-2-YL)SPIRO[4.5]DEC-6-ENE'>6BW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5-epiaristolochene_synthase 5-epiaristolochene synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.3.61 4.2.3.61] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ikh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikh OCA], [https://pdbe.org/5ikh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ikh RCSB], [https://www.ebi.ac.uk/pdbsum/5ikh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ikh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ikh OCA], [http://pdbe.org/5ikh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ikh RCSB], [http://www.ebi.ac.uk/pdbsum/5ikh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ikh ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC]] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
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[https://www.uniprot.org/uniprot/5EAS_TOBAC 5EAS_TOBAC] Catalyzes the cyclization of trans,trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: 5-epiaristolochene synthase]]
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[[Category: Large Structures]]
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[[Category: Bowman, M]]
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[[Category: Nicotiana tabacum]]
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[[Category: Koo, H J]]
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[[Category: Bowman M]]
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[[Category: Louie, G V]]
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[[Category: Koo HJ]]
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[[Category: Maille, P E.O]]
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[[Category: Louie GV]]
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[[Category: Noel, J P]]
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[[Category: Noel JP]]
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[[Category: Lyase]]
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[[Category: O'Maille PE]]
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[[Category: Premnaspirodiene]]
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[[Category: Tea]]
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[[Category: Teas-m4]]
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[[Category: Terpene synthase]]
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Current revision

Tobacco 5-epi-aristolochene synthase M4 mutant with (-)-premnaspirodiene

PDB ID 5ikh

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