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5kc1

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==Structure of the C-terminal dimerization domain of Atg38==
==Structure of the C-terminal dimerization domain of Atg38==
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<StructureSection load='5kc1' size='340' side='right' caption='[[5kc1]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<StructureSection load='5kc1' size='340' side='right'caption='[[5kc1]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5kc1]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5KC1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5kc1]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5KC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5KC1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5kc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kc1 OCA], [http://pdbe.org/5kc1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5kc1 RCSB], [http://www.ebi.ac.uk/pdbsum/5kc1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5kc1 ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5kc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5kc1 OCA], [https://pdbe.org/5kc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5kc1 RCSB], [https://www.ebi.ac.uk/pdbsum/5kc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5kc1 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/ATG38_YEAST ATG38_YEAST]] Autophagy-related protein required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG38 is required for the integrity of the active PI3-kinase complex I by maintaining an association between VPS15-VPS34 and ATG1P-VPS30 subcomplexes.<ref>PMID:24165940</ref>
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[https://www.uniprot.org/uniprot/ATG38_YEAST ATG38_YEAST] Autophagy-related protein required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG38 is required for the integrity of the active PI3-kinase complex I by maintaining an association between VPS15-VPS34 and ATG1P-VPS30 subcomplexes.<ref>PMID:24165940</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Garcia-Ortegon, M]]
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[[Category: Large Structures]]
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[[Category: Johnson, C M]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Masson, G R]]
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[[Category: Garcia-Ortegon M]]
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[[Category: Ohashi, Y]]
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[[Category: Johnson CM]]
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[[Category: Perisic, O]]
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[[Category: Masson GR]]
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[[Category: Soler, N]]
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[[Category: Ohashi Y]]
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[[Category: Williams, R J]]
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[[Category: Perisic O]]
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[[Category: Zhang, L]]
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[[Category: Soler N]]
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[[Category: Atg38]]
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[[Category: Williams RJ]]
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[[Category: Autophagy]]
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[[Category: Zhang L]]
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[[Category: Coiled-coil]]
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[[Category: Dimerization]]
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[[Category: Endocytosis]]
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[[Category: Nrbf2]]
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Current revision

Structure of the C-terminal dimerization domain of Atg38

PDB ID 5kc1

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