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5gio

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==Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates==
==Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates==
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<StructureSection load='5gio' size='340' side='right' caption='[[5gio]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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<StructureSection load='5gio' size='340' side='right'caption='[[5gio]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5gio]] is a 15 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5gio]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GIO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.604&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5gip|5gip]], [[5gin|5gin]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gio OCA], [http://pdbe.org/5gio PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gio RCSB], [http://www.ebi.ac.uk/pdbsum/5gio PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gio ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gio OCA], [https://pdbe.org/5gio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gio RCSB], [https://www.ebi.ac.uk/pdbsum/5gio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gio ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/A0A0E3JUC9_SULSF A0A0E3JUC9_SULSF]] Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.[HAMAP-Rule:MF_00351] [[http://www.uniprot.org/uniprot/A0A0E3JZF7_SULSF A0A0E3JZF7_SULSF]] Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.[HAMAP-Rule:MF_00326]
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[https://www.uniprot.org/uniprot/Q97ZH3_SACS2 Q97ZH3_SACS2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lin, J]]
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[[Category: Large Structures]]
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[[Category: Yang, Z]]
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[[Category: Saccharolobus solfataricus]]
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[[Category: Ye, K]]
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[[Category: Lin J]]
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[[Category: 2'-o-methylation]]
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[[Category: Yang Z]]
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[[Category: Guide rna]]
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[[Category: Ye K]]
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[[Category: Rnp]]
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[[Category: Transferase-rna complex]]
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Current revision

Crystal structure of box C/D RNP with 12 nt guide regions and 13 nt substrates

PDB ID 5gio

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