5h1h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of SLBA, a chimera of SFTI== | |
| + | <StructureSection load='5h1h' size='340' side='right'caption='[[5h1h]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5h1h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H1H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H1H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h1h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h1h OCA], [https://pdbe.org/5h1h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h1h RCSB], [https://www.ebi.ac.uk/pdbsum/5h1h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h1h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An orally active and metabolically stable peptide TIBA was successfully engineered as a chimera by fusing an analgesic bradykinin receptor antagonist peptide and the trypsin inhibitory loop of sunflower trypsin inhibitor-1. As a fusion cyclic peptide, the metabolically labile analgesic peptide is protected from degradation by exopeptidases as well as the endopeptidases, and its serum half-life extended from <5 min to >6 h as a chimera. Moreover, the chimera TIBA was also found to be orally active in an animal pain model using a hot plate assay. | ||
| - | + | An Orally Active Bradykinin B1 Receptor Antagonist Engineered as a Bifunctional Chimera of Sunflower Trypsin Inhibitor.,Qiu Y, Taichi M, Wei N, Yang H, Luo KQ, Tam JP J Med Chem. 2017 Jan 12;60(1):504-510. doi: 10.1021/acs.jmedchem.6b01011. Epub, 2016 Dec 15. PMID:27977181<ref>PMID:27977181</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 5h1h" style="background-color:#fffaf0;"></div> |
| - | [[Category: Tam | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helianthus annuus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Tam JP]] | ||
| + | [[Category: Xiao T]] | ||
Current revision
NMR structure of SLBA, a chimera of SFTI
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