1pft

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[[Image:1pft.gif|left|200px]]
 
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{{Structure
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==N-TERMINAL DOMAIN OF TFIIB, NMR==
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|PDB= 1pft |SIZE=350|CAPTION= <scene name='initialview01'>1pft</scene>
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<StructureSection load='1pft' size='340' side='right'caption='[[1pft]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[1pft]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PFT FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE= PYROCOCCUS FURIOSUS TFIIB GENE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 Pyrococcus furiosus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pft OCA], [https://pdbe.org/1pft PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pft RCSB], [https://www.ebi.ac.uk/pdbsum/1pft PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pft ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pft FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pft OCA], [http://www.ebi.ac.uk/pdbsum/1pft PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pft RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/TF2B_PYRFU TF2B_PYRFU] Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pf/1pft_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pft ConSurf].
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<div style="clear:both"></div>
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'''N-TERMINAL DOMAIN OF TFIIB, NMR'''
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==See Also==
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*[[Transcription initiation factors 3D structures|Transcription initiation factors 3D structures]]
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__TOC__
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==Overview==
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</StructureSection>
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The three-dimensional structure of the N-terminal domain of an archaeal TFIIB, which has high sequence homology with eucaryal analogues, is strikingly similar to that of the C-terminal zinc ribbon of the eucaryal transcription elongation factor TFIIB.
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[[Category: Large Structures]]
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==About this Structure==
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1PFT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PFT OCA].
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==Reference==
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The N-terminal domain of TFIIB from Pyrococcus furiosus forms a zinc ribbon., Zhu W, Zeng Q, Colangelo CM, Lewis M, Summers MF, Scott RA, Nat Struct Biol. 1996 Feb;3(2):122-4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8564536 8564536]
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[[Category: Pyrococcus furiosus]]
[[Category: Pyrococcus furiosus]]
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[[Category: Single protein]]
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[[Category: Colangelo CM]]
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[[Category: Colangelo, C M.]]
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[[Category: Lewis LM]]
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[[Category: Lewis, L M.]]
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[[Category: Scott RA]]
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[[Category: Scott, R A.]]
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[[Category: Summers MF]]
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[[Category: Summers, M F.]]
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[[Category: Zeng Q]]
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[[Category: Zeng, Q.]]
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[[Category: Zhu W]]
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[[Category: Zhu, W.]]
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[[Category: n-terminal domain]]
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[[Category: tfiib]]
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[[Category: transcription initiation factor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:59:05 2008''
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N-TERMINAL DOMAIN OF TFIIB, NMR

PDB ID 1pft

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