5m0t
From Proteopedia
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(New page: '''Unreleased structure''' The entry 5m0t is ON HOLD until Paper Publication Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH== | |
| + | <StructureSection load='5m0t' size='340' side='right'caption='[[5m0t]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5m0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_japonicus Aspergillus japonicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5M0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5M0T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5m0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5m0t OCA], [https://pdbe.org/5m0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5m0t RCSB], [https://www.ebi.ac.uk/pdbsum/5m0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5m0t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1L1QK38_ASPJA A0A1L1QK38_ASPJA] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Aj_EasH is a non-heme iron- and alpha-keto-glutarate-dependent oxidase that is responsible for an unusual cyclopropyl ring formation in the biosynthesis of the fungal ergot alkaloid cycloclavine. The three dimensional structure of Aj_EasH (2.2 A resolution) reported here provides insight into the mechanism of this unusual and complex reaction. | ||
| - | + | Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis.,Jakubczyk D, Caputi L, Stevenson CE, Lawson DM, O'Connor SE Chem Commun (Camb). 2016 Dec 6;52(99):14306-14309. PMID:27885368<ref>PMID:27885368</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5m0t" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Aspergillus japonicus]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Caputi L]] | ||
| + | [[Category: Jakubczyk D]] | ||
| + | [[Category: Lawson DM]] | ||
| + | [[Category: O'Connor SE]] | ||
| + | [[Category: Stevenson CEM]] | ||
Current revision
Alpha-ketoglutarate-dependent non-heme iron oxygenase EasH
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