This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5tin
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5tin is ON HOLD until Paper Publication Authors: Shaffer, P.L., Huang, X., Chen, H. Description: Crystal Structure of Human Glycine Receptor alpha-...) |
|||
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607== | |
| - | + | <StructureSection load='5tin' size='340' side='right'caption='[[5tin]], [[Resolution|resolution]] 2.61Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5tin]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TIN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TIN FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.61Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7C6:(3S,3AS,9BS)-2-[(2H-1,3-BENZODIOXOL-5-YL)SULFONYL]-3,5-DIMETHYL-1,2,3,3A,5,9B-HEXAHYDRO-4H-PYRROLO[3,4-C][1,6]NAPHTHYRIDIN-4-ONE'>7C6</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tin FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tin OCA], [https://pdbe.org/5tin PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tin RCSB], [https://www.ebi.ac.uk/pdbsum/5tin PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tin ProSAT]</span></td></tr> |
| - | [[Category: Chen | + | </table> |
| - | [[Category: Shaffer | + | == Function == |
| + | [https://www.uniprot.org/uniprot/GLRA3_HUMAN GLRA3_HUMAN] The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chen H]] | ||
| + | [[Category: Huang X]] | ||
| + | [[Category: Shaffer PL]] | ||
Current revision
Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607
| |||||||||||
