1pjb

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[[Image:1pjb.jpg|left|200px]]
 
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{{Structure
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==L-ALANINE DEHYDROGENASE==
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|PDB= 1pjb |SIZE=350|CAPTION= <scene name='initialview01'>1pjb</scene>, resolution 2.1&Aring;
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<StructureSection load='1pjb' size='340' side='right'caption='[[1pjb]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1pjb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJB FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Alanine_dehydrogenase Alanine dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.1.1 1.4.1.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= ALADH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=32060 Phormidium lapideum])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjb OCA], [https://pdbe.org/1pjb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjb RCSB], [https://www.ebi.ac.uk/pdbsum/1pjb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjb ProSAT]</span></td></tr>
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|DOMAIN=
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</table>
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|RELATEDENTRY=
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== Function ==
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pjb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjb OCA], [http://www.ebi.ac.uk/pdbsum/1pjb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pjb RCSB]</span>
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[https://www.uniprot.org/uniprot/O52942_PHOLP O52942_PHOLP]
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}}
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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'''L-ALANINE DEHYDROGENASE'''
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pj/1pjb_consurf.spt"</scriptWhenChecked>
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==Overview==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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The structure of the hexameric L-alanine dehydrogenase from Phormidium lapideum reveals that the subunit is constructed from two domains, each having the common dinucleotide binding fold. Despite there being no sequence similarity, the fold of alanine dehydrogenase is closely related to that of the family of D-2-hydroxyacid dehydrogenases, with a similar location of the active site, suggesting that these enzymes are related by divergent evolution. L-alanine dehydrogenase and the 2-hydroxyacid dehydrogenases also use equivalent functional groups to promote substrate recognition and catalysis. However, they are arranged differently on the enzyme surface, which has the effect of directing opposite faces of the keto acid to the dinucleotide in each case, forcing a change in absolute configuration of the product.
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pjb ConSurf].
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1PJB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Phormidium_lapideum Phormidium lapideum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJB OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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Analysis of the structure and substrate binding of Phormidium lapideum alanine dehydrogenase., Baker PJ, Sawa Y, Shibata H, Sedelnikova SE, Rice DW, Nat Struct Biol. 1998 Jul;5(7):561-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665169 9665169]
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[[Category: Large Structures]]
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[[Category: Alanine dehydrogenase]]
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[[Category: Phormidium lapideum]]
[[Category: Phormidium lapideum]]
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[[Category: Single protein]]
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[[Category: Baker PJ]]
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[[Category: Baker, P J.]]
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[[Category: Rice DW]]
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[[Category: Rice, D W.]]
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[[Category: Sawa Y]]
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[[Category: Sawa, Y.]]
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[[Category: Sedelnikova SE]]
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[[Category: Sedelnikova, S E.]]
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[[Category: Shibata H]]
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[[Category: Shibata, H.]]
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[[Category: nad]]
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[[Category: oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:00:26 2008''
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Current revision

L-ALANINE DEHYDROGENASE

PDB ID 1pjb

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