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5e5m
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==Crystal structure of mouse CTLA-4 in complex with nanobody== | ==Crystal structure of mouse CTLA-4 in complex with nanobody== | ||
| - | <StructureSection load='5e5m' size='340' side='right' caption='[[5e5m]], [[Resolution|resolution]] 2.18Å' scene=''> | + | <StructureSection load='5e5m' size='340' side='right'caption='[[5e5m]], [[Resolution|resolution]] 2.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5e5m]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5M OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5e5m]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Camelidae Camelidae] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E5M FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.182Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e5m OCA], [https://pdbe.org/5e5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e5m RCSB], [https://www.ebi.ac.uk/pdbsum/5e5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e5m ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CTLA4_MOUSE CTLA4_MOUSE] Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity). |
| + | |||
| + | ==See Also== | ||
| + | *[[CTLA-4|CTLA-4]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Camelidae]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | [[Category: | + | [[Category: Almo SC]] |
| - | [[Category: | + | [[Category: Bonanno JB]] |
| - | [[Category: | + | [[Category: Fedorov AA]] |
| - | [[Category: | + | [[Category: Fedorov EV]] |
| - | [[Category: | + | [[Category: Samanta D]] |
Current revision
Crystal structure of mouse CTLA-4 in complex with nanobody
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