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5l04

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==STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1==
==STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1==
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<StructureSection load='5l04' size='340' side='right' caption='[[5l04]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='5l04' size='340' side='right'caption='[[5l04]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5l04]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L04 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5l04]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L04 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5L04 FirstGlance]. <br>
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</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l04 OCA], [http://pdbe.org/5l04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l04 RCSB], [http://www.ebi.ac.uk/pdbsum/5l04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l04 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5l04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l04 OCA], [https://pdbe.org/5l04 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5l04 RCSB], [https://www.ebi.ac.uk/pdbsum/5l04 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5l04 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. [[http://www.uniprot.org/uniprot/INLR1_HUMAN INLR1_HUMAN]] The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<ref>PMID:12521379</ref> <ref>PMID:12469119</ref> <ref>PMID:12483210</ref>
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[https://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.
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== References ==
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<references/>
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==See Also==
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*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
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*[[Janus kinase 3D structures|Janus kinase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Non-specific protein-tyrosine kinase]]
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[[Category: Homo sapiens]]
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[[Category: Lubkowski, J]]
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[[Category: Large Structures]]
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[[Category: Wlodawer, A]]
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[[Category: Lubkowski J]]
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[[Category: Zhang, D]]
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[[Category: Wlodawer A]]
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[[Category: Complex of jak1 and interferon lambda 1]]
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[[Category: Zhang D]]
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[[Category: Ferm domain]]
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[[Category: Intracellular domain of ifnlr1]]
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[[Category: Jak kinase]]
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[[Category: Sh2-like domain]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

STRUCTURE OF INTERFERON LAMBDA 1 RECEPTOR WITH HUMAN KINASE JAK1

PDB ID 5l04

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