5l04

<StructureSection load='5l04' size='340' side='right' caption='[[5l04]], [[Resolution|resolution]] 2.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[5l04]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L04 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L04 FirstGlance]. <br>

</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Non-specific_protein-tyrosine_kinase Non-specific protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.2 2.7.10.2] </span></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l04 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l04 OCA], [http://pdbe.org/5l04 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l04 RCSB], [http://www.ebi.ac.uk/pdbsum/5l04 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l04 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/JAK1_HUMAN JAK1_HUMAN]] Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor. [[http://www.uniprot.org/uniprot/INLR1_HUMAN INLR1_HUMAN]] The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium.<ref>PMID:12521379</ref> <ref>PMID:12469119</ref> <ref>PMID:12483210</ref>

== References ==

[[Category: Non-specific protein-tyrosine kinase]]

[[Category: Lubkowski, J]]

[[Category: Wlodawer, A]]

[[Category: Zhang, D]]

[[Category: Complex of jak1 and interferon lambda 1]]

[[Category: Transferase-transferase inhibitor complex]]