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1pl9

From Proteopedia

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[[Image:1pl9.gif|left|200px]]
 
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{{Structure
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==Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP==
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|PDB= 1pl9 |SIZE=350|CAPTION= <scene name='initialview01'>1pl9</scene>, resolution 2.9&Aring;
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<StructureSection load='1pl9' size='340' side='right'caption='[[1pl9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene>
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<table><tr><td colspan='2'>[[1pl9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PL9 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/3-deoxy-8-phosphooctulonate_synthase 3-deoxy-8-phosphooctulonate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.55 2.5.1.55] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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|GENE= KDSA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPE:3-FLUORO-2-(PHOSPHONOOXY)PROPANOIC+ACID'>FPE</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [https://pdbe.org/1pl9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB], [https://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pl9 ProSAT]</span></td></tr>
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|RELATEDENTRY=[[1g7u|1G7U]], [[1d9e|1D9E]], [[1phq|1PHQ]], [[1phw|1PHW]], [[1q3n|1Q3N]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pl9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pl9 OCA], [http://www.ebi.ac.uk/pdbsum/1pl9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pl9 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/KDSA_ECOLI KDSA_ECOLI] Synthesis of KDO 8-P which is required for lipid A maturation and cellular growth.[HAMAP-Rule:MF_00056]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pl/1pl9_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pl9 ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP'''
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==See Also==
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*[[Kdo-8-phosphate synthase|Kdo-8-phosphate synthase]]
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__TOC__
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==About this Structure==
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</StructureSection>
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1PL9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PL9 OCA].
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[[Category: 3-deoxy-8-phosphooctulonate synthase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Adir, N.]]
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[[Category: Adir N]]
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[[Category: Baasov, T.]]
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[[Category: Baasov T]]
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[[Category: Belakhov, V.]]
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[[Category: Belakhov V]]
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[[Category: Rabkin, E.]]
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[[Category: Rabkin E]]
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[[Category: Vainer, R.]]
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[[Category: Vainer R]]
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[[Category: beta-alpha-barrel]]
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[[Category: flourinated analog]]
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[[Category: lipopolysaccharide]]
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[[Category: lyase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:16 2008''
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Current revision

Crystal structure of KDO8P synthase in its binary complex with substrate analog Z-FPEP

PDB ID 1pl9

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