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| - | [[Image:1pm3.gif|left|200px]] | |
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| - | {{Structure
| + | ==MTH1859== |
| - | |PDB= 1pm3 |SIZE=350|CAPTION= <scene name='initialview01'>1pm3</scene>, resolution 3.15Å
| + | <StructureSection load='1pm3' size='340' side='right'caption='[[1pm3]], [[Resolution|resolution]] 3.15Å' scene=''> |
| - | |SITE=
| + | == Structural highlights == |
| - | |LIGAND=
| + | <table><tr><td colspan='2'>[[1pm3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PM3 FirstGlance]. <br> |
| - | |ACTIVITY=
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.15Å</td></tr> |
| - | |GENE=
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm3 OCA], [https://pdbe.org/1pm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pm3 RCSB], [https://www.ebi.ac.uk/pdbsum/1pm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pm3 ProSAT], [https://www.topsan.org/Proteins/NESGC/1pm3 TOPSAN]</span></td></tr> |
| - | |DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1873 COG1873]</span>
| + | </table> |
| - | |RELATEDENTRY= | + | == Function == |
| - | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1pm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pm3 OCA], [http://www.ebi.ac.uk/pdbsum/1pm3 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1pm3 RCSB]</span> | + | [https://www.uniprot.org/uniprot/O27887_METTH O27887_METTH] |
| - | }}
| + | __TOC__ |
| - | | + | </StructureSection> |
| - | '''MTH1859'''
| + | [[Category: Large Structures]] |
| - | | + | |
| - | | + | |
| - | ==Overview==
| + | |
| - | MTH1859 from Methanobacterium thermoautotrophicum is a 77 residue protein representing a conserved family of functionally uncharacterized proteins. We solved the crystal structure of MTH1859 by single wavelength anomalous diffraction phasing using selenomethionine labeled protein. MTH1859 adopts a mainly anti-parallel all-beta-fold. The beta-sheet is heavily bent to form a U-structure that is closed through a loop. The monomer structure possesses similarities to the photoreaction center (PRC) domain fold, but the protein employs a unique oligomerization scheme. Two monomers of MTH1859 occupy the asymmetric unit and dimerize in a head-to-head fashion. Crystal packing interactions identify a second protein-protein interaction interface at the MTH1859 tails which can simultaneously bind two partner molecules. These interactions lead to the formation of a honeycomb structure and suggest that the family of MTH1859-like proteins might function as adapters for protein complex assembly.
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| - | | + | |
| - | ==About this Structure==
| + | |
| - | 1PM3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Methanothermobacter_thermautotrophicus Methanothermobacter thermautotrophicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PM3 OCA].
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| - | | + | |
| - | ==Reference== | + | |
| - | Crystal structure of the putative adapter protein MTH1859., Ye H, Chen TC, Xu X, Pennycooke M, Wu H, Steegborn C, J Struct Biol. 2004 Nov;148(2):251-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15477104 15477104]
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| | [[Category: Methanothermobacter thermautotrophicus]] | | [[Category: Methanothermobacter thermautotrophicus]] |
| - | [[Category: Single protein]]
| + | [[Category: Steegborn C]] |
| - | [[Category: NESG, Northeast Structural Genomics Consortium.]]
| + | [[Category: Wu H]] |
| - | [[Category: Steegborn, C.]] | + | [[Category: Ye H]] |
| - | [[Category: Wu, H.]] | + | |
| - | [[Category: Ye, H.]] | + | |
| - | [[Category: nesg]]
| + | |
| - | [[Category: northeast structural genomics consortium]]
| + | |
| - | [[Category: protein structure initiative]]
| + | |
| - | [[Category: psi]]
| + | |
| - | [[Category: structural genomic]]
| + | |
| - | [[Category: unknown function]]
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| - | | + | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:01:28 2008''
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