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5hzp

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==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.==
==Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.==
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<StructureSection load='5hzp' size='340' side='right' caption='[[5hzp]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
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<StructureSection load='5hzp' size='340' side='right'caption='[[5hzp]], [[Resolution|resolution]] 2.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hzp]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HZP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hzp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_M49 Streptococcus pyogenes serotype M49]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HZP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.74&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyp|5hyp]], [[5hyt|5hyt]], [[5i0q|5i0q]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzp OCA], [https://pdbe.org/5hzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hzp RCSB], [https://www.ebi.ac.uk/pdbsum/5hzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hzp OCA], [http://pdbe.org/5hzp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hzp RCSB], [http://www.ebi.ac.uk/pdbsum/5hzp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hzp ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/M49_STRP9 M49_STRP9]] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis. [[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
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[https://www.uniprot.org/uniprot/M49_STRP9 M49_STRP9] This protein is one of the different antigenic serotypes of protein M. Protein M is closely associated with virulence of the bacterium and can render the organism resistant to phagocytosis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bahn-Suh, A J]]
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[[Category: Homo sapiens]]
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[[Category: Buffalo, C Z]]
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[[Category: Large Structures]]
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[[Category: Ghosh, P]]
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[[Category: Streptococcus pyogenes serotype M49]]
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[[Category: Compliment]]
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[[Category: Bahn-Suh AJ]]
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[[Category: Hypervariable antigen]]
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[[Category: Buffalo CZ]]
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[[Category: Immune system]]
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[[Category: Ghosh P]]
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[[Category: M protein]]
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[[Category: Streptococcus pyogene]]
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Current revision

Structure of human C4b-binding protein alpha chain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M49 protein.

PDB ID 5hzp

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