5hyp

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==Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein==
==Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein==
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<StructureSection load='5hyp' size='340' side='right' caption='[[5hyp]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
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<StructureSection load='5hyp' size='340' side='right'caption='[[5hyp]], [[Resolution|resolution]] 3.02&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5hyp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYP FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5hyu|5hyu]], [[5hyt|5hyt]], [[5hzp|5hzp]], [[5i0q|5i0q]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.024&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [http://pdbe.org/5hyp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [http://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hyp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hyp OCA], [https://pdbe.org/5hyp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hyp RCSB], [https://www.ebi.ac.uk/pdbsum/5hyp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hyp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN]] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
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[https://www.uniprot.org/uniprot/C4BPA_HUMAN C4BPA_HUMAN] Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bahn-Suh, A J]]
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[[Category: Homo sapiens]]
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[[Category: Buffalo, C Z]]
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[[Category: Large Structures]]
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[[Category: Ghosh, P]]
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[[Category: Streptococcus pyogenes]]
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[[Category: Complement]]
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[[Category: Bahn-Suh AJ]]
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[[Category: Hypervariable antigen]]
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[[Category: Buffalo CZ]]
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[[Category: Immune system]]
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[[Category: Ghosh P]]
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[[Category: M protein]]
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[[Category: Streptococcus pyogene]]
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Current revision

Structure of human C4b-binding protein alpha cain CCP domains 1 and 2 in complex with the hypervariable region of group A Streptococcus M28 protein

PDB ID 5hyp

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