5t53
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE ESCO1== | |
| - | + | <StructureSection load='5t53' size='340' side='right'caption='[[5t53]], [[Resolution|resolution]] 2.70Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5t53]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5T53 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5T53 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.699Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5t53 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5t53 OCA], [https://pdbe.org/5t53 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5t53 RCSB], [https://www.ebi.ac.uk/pdbsum/5t53 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5t53 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Marmorstein | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/ESCO1_HUMAN ESCO1_HUMAN] Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.<ref>PMID:14576321</ref> <ref>PMID:15958495</ref> <ref>PMID:18614053</ref> <ref>PMID:19907496</ref> |
| - | [[Category: | + | == References == |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liszczak GP]] | ||
| + | [[Category: Maguire A]] | ||
| + | [[Category: Marmorstein R]] | ||
| + | [[Category: Olia AS]] | ||
| + | [[Category: Rivera-Colon Y]] | ||
Current revision
MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE ESCO1
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