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5tpa
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5tpa is ON HOLD Authors: Wallweber, H.J.A., Lupardus, P.J. Description: Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500)== | |
| + | <StructureSection load='5tpa' size='340' side='right'caption='[[5tpa]], [[Resolution|resolution]] 2.48Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5tpa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TPA FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7H2:(1R,2R)-2-(2-{[5-CHLORO-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL]METHYL}-7-METHYL-4-OXO-4H-PYRIDO[1,2-A]PYRIMIDIN-6-YL)CYCLOPROPANE-1-CARBONITRILE'>7H2</scene>, <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpa OCA], [https://pdbe.org/5tpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tpa RCSB], [https://www.ebi.ac.uk/pdbsum/5tpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpa ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] Landau-Kleffner syndrome;Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation;Continuous spikes and waves during sleep;Rolandic epilepsy;Rolandic epilepsy - speech dyspraxia. The disease is caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving GRIN2A has been found in a family with epilepsy and neurodevelopmental defects. Translocation t(16;17)(p13.2;q11.2). GRIN2A somatic mutations have been frequently found in cutaneous malignant melanoma, suggesting that the glutamate signaling pathway may play a role in the pathogenesis of melanoma.<ref>PMID:21499247</ref> <ref>PMID:24455489</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NMDE1_HUMAN NMDE1_HUMAN] NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits. | ||
| - | + | ==See Also== | |
| - | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: Lupardus | + | </StructureSection> |
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lupardus PJ]] | ||
| + | [[Category: Wallweber HJA]] | ||
Current revision
Structure of the human GluN1/GluN2A LBD in complex with compound 9 (GNE3500)
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