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5tpg
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 5tpg is ON HOLD Authors: Stein, A.J., Goldberg, D.R., De Lombaert, S., Holt, M.C. Description: Optimization of spirocyclic proline tryptophanhydrox...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors== | |
| + | <StructureSection load='5tpg' size='340' side='right'caption='[[5tpg]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5tpg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5TPG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5TPG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7H5:(3S)-8-(2-AMINO-6-{(1R)-1-[5-CHLORO-3-(METHYLSULFONYL)[1,1-BIPHENYL]-2-YL]-2,2,2-TRIFLUOROETHOXY}PYRIMIDIN-4-YL)-2,8-DIAZASPIRO[4.5]DECANE-3-CARBOXYLIC+ACID'>7H5</scene>, <scene name='pdbligand=CCN:ACETONITRILE'>CCN</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5tpg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5tpg OCA], [https://pdbe.org/5tpg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5tpg RCSB], [https://www.ebi.ac.uk/pdbsum/5tpg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5tpg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TPH1_HUMAN TPH1_HUMAN] | ||
| - | + | ==See Also== | |
| - | + | *[[Hydroxylases 3D structures|Hydroxylases 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Holt | + | [[Category: De Lombaert S]] |
| - | [[Category: | + | [[Category: Goldberg DR]] |
| + | [[Category: Holt MC]] | ||
| + | [[Category: Stein AJ]] | ||
Current revision
Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors
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