5ife

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==Crystal structure of the human SF3b core complex==
==Crystal structure of the human SF3b core complex==
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<StructureSection load='5ife' size='340' side='right' caption='[[5ife]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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<StructureSection load='5ife' size='340' side='right'caption='[[5ife]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5ife]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IFE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IFE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5ife]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IFE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IFE FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ife FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ife OCA], [http://pdbe.org/5ife PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ife RCSB], [http://www.ebi.ac.uk/pdbsum/5ife PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ife ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ife FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ife OCA], [https://pdbe.org/5ife PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ife RCSB], [https://www.ebi.ac.uk/pdbsum/5ife PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ife ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SF3B3_HUMAN SF3B3_HUMAN]] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. [[http://www.uniprot.org/uniprot/PHF5A_HUMAN PHF5A_HUMAN]] Acts as a transcriptional regulator by binding to the GJA1/Cx43 promoter and enhancing its up-regulation by ESR1/ER-alpha. Also involved in pre-mRNA splicing.<ref>PMID:12234937</ref> [[http://www.uniprot.org/uniprot/SF3B1_HUMAN SF3B1_HUMAN]] Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
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[https://www.uniprot.org/uniprot/SF3B5_HUMAN SF3B5_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5ife" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5ife" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cretu, C]]
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[[Category: Homo sapiens]]
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[[Category: Dybkov, O]]
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[[Category: Large Structures]]
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[[Category: Laurentiis, E De]]
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[[Category: Cretu C]]
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[[Category: Luhrmann, R]]
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[[Category: De Laurentiis E]]
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[[Category: Pena, V]]
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[[Category: Dybkov O]]
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[[Category: Will, C L]]
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[[Category: Luhrmann R]]
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[[Category: Essential splicing factor]]
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[[Category: Pena V]]
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[[Category: Pre-mrna splicing]]
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[[Category: Will CL]]
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[[Category: Splicing]]
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[[Category: U2 snrnp]]
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Current revision

Crystal structure of the human SF3b core complex

PDB ID 5ife

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