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5jfg

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==Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA==
==Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA==
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<StructureSection load='5jfg' size='340' side='right' caption='[[5jfg]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
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<StructureSection load='5jfg' size='340' side='right'caption='[[5jfg]], [[Resolution|resolution]] 1.77&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5jfg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JFG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JFG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5jfg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JFG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.77&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jfg OCA], [http://pdbe.org/5jfg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jfg RCSB], [http://www.ebi.ac.uk/pdbsum/5jfg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jfg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5jfg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jfg OCA], [https://pdbe.org/5jfg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5jfg RCSB], [https://www.ebi.ac.uk/pdbsum/5jfg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5jfg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RADA_PYRFU RADA_PYRFU]] Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
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[https://www.uniprot.org/uniprot/RADA_PYRFU RADA_PYRFU] Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules.
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==See Also==
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*[[Resolvase 3D structures|Resolvase 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Abell, C]]
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[[Category: Large Structures]]
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[[Category: Blundell, T L]]
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[[Category: Pyrococcus furiosus]]
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[[Category: Fischer, G]]
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[[Category: Synthetic construct]]
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[[Category: Hyvonen, M]]
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[[Category: Abell C]]
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[[Category: Marsh, M]]
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[[Category: Blundell TL]]
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[[Category: Morgan, M]]
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[[Category: Fischer G]]
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[[Category: Moschetti, T]]
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[[Category: Hyvonen M]]
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[[Category: Ng, H]]
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[[Category: Marsh M]]
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[[Category: Scott, D]]
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[[Category: Morgan M]]
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[[Category: Sharpe, T]]
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[[Category: Moschetti T]]
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[[Category: Skidmore, J]]
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[[Category: Ng H]]
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[[Category: Venkitaraman, A]]
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[[Category: Scott D]]
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[[Category: Dna repair]]
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[[Category: Sharpe T]]
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[[Category: Fragment based drug design]]
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[[Category: Skidmore J]]
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[[Category: Humanisation]]
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[[Category: Venkitaraman A]]
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[[Category: Hydrolase]]
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Current revision

Structure of humanised RadA-mutant humRadA22F in complex with peptide FHTA

PDB ID 5jfg

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